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PharmaPoint: Osteoporosis - US Drug Forecast and Market Analysis to 2022

3.1.3 Risk Factors 17
3.1.4 Quality of Life 17
3.2 Symptoms 18
4 Disease Management 19
4.1 Treatment Overview 19
4.1.1 Diagnosis and Referral 19
4.1.2 Treatment Guidelines 20
4.1.3 Disease Management 22
4.2 United States 25
4.2.1 Diagnosis 25
4.2.2 Clinical Practice 26
5 Competitive Assessment 27
5.1 Overview 27
5.2 Strategic Competitor Assessment 27
5.3 Product Profiles – Major Brands 31
5.3.1 Actonel (risedronate sodium) 31
5.3.2 Evista (raloxifene hydrochloride) 34
5.3.3 Reclast (zolendronic acid) 37
5.3.4 Forteo (teriparatide) 40
5.3.5 Prolia (denosumab) 44
5.3.6 Protelos (strontium ranelate) 47
5.3.7 Miacalcin and Fortical (calcitonin-salmon) 50
5.3.8 Viviant/Conbriza (bazedoxifene) 54
5.3.9 Recalbon/Bonoteo (minodronic acid hydrate) 57
5.3.10 Alendronate sodium 60
5.3.11 Ibandronate 61
6 Opportunity and Unmet Need 63
6.1 Overview 63
6.2 Unmet Needs 64
6.2.1 Disease Awareness and Early Diagnosis 64
6.2.2 Patient Compliance 65
6.2.3 Efficacy 66
6.2.4 Safety 67
6.2.5 Treatment Cost 67
6.2.6 Earlier Intervention 68
6.3 Unmet Needs Gap Analysis 69
6.4 Opportunity 1: Dual-Action Therapies 70
6.5 Opportunity 2: Osteoporosis Prevention Therapies 71
6.6 Opportunity 3: Dosing and Administration 72
7 Pipeline Assessment 73
7.1 Overview 73
7.2 Promising Drugs in Clinical Development 74
7.2.1 Aprela (bazedoxifene and conjugated estrogens) 76
7.2.2 Romosozumab (AMG-785) 82
7.2.3 Odanacatib 88
7.2.4 BA-058 94
7.2.5 PTH(1-31)NH2 99
7.2.6 Ostora (recombinant salmon calcitonin) 104
8 Market Outlook 109
8.1 United States 109
8.1.1 Forecast 109
8.1.2 Key Events 112
8.1.3 Drivers and Barriers 112
9 Appendix 115
9.1 Bibliography 115
9.2 Abbreviations 122
9.3 Methodology
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