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PharmaPoint: Multiple Sclerosis - US Drug Forecast and Market Analysis to 2022
Date:5/14/2013

gs from 2012-2022 in the US1 Table of Contents1 Table of Contents 41.1 List of Tables 71.2 List of Figures 92 Introduction 102.1 Catalyst 102.2 Related Reports 113 Disease Overview 133.1 Etiology and Pathophysiology 133.1.1 Etiology 133.1.2 Pathophysiology 143.1.3 Classification of Multiple Sclerosis 153.2 Symptoms 173.2.1 Prognosis 183.2.2 Quality of Life 194 Disease Management 204.1 Diagnosis 204.2 Treatment Overview 234.2.1 Management of Acute Relapse 244.2.2 Treatment with Disease-Modifying Therapies 244.2.3 Symptomatic Therapies 274.3 US 284.3.1 Diagnosis 284.3.2 Clinical Practice 295 Competitive Assessment 315.1 Overview 315.2 Strategic Competitor Assessment 325.3 Product Profiles – Major Brands 345.3.1 Betaseron/Betaferon (interferon beta-1b) 345.3.2 Avonex (interferon beta-1a) 395.3.3 Rebif (interferon beta-1a) 445.3.4 Copaxone (glatiramer acetate; copolymer-1) 485.3.5 Tysabri (natalizumab) 525.3.6 Gilenya/Imusera (fingolimod; FTY720) 575.3.7 Aubagio (teriflunomide) 625.3.8 Other Disease–Modifying Therapies 676 Opportunity and Unmet Need 686.1 Overview 686.2 Unmet Needs 696.2.1 Currently Available MS Drugs Only Provide Partial Benefits 696.2.2 The High Cost of MS Drugs Could Continue to Price out Patients 706.2.3 Safety and Tolerability of Therapy is Undermined by Side Effects 716.2.4 Effective Treatments for Progressive MS Are Still Elusive 726.2.5 Inconvenient Route of Administration and Frequent Dosing Limits Compliance 736.2.6 The Lack of Predictive Biomarkers Delays MS Diagnosis 746.3 Unmet Needs Gap Analysis 756.4 Opportunities 766.4.1 Treatments for Progressive MS 766.4.2 Targeting Patients with Clinically Isolated Syndrome 767 Pipeline Assessment 777.1 Overview 777.2 Promising Drugs in Clinical Development 787.2.1 BG-12 (dimethyl fumarate; BG00012) 817.2.2 Lemtrada (alemtuzumab) 867.2.3 Laquinimod (ABR-215062) 927.2.4 Daclizumab High-Yield Process (HYP) 977.2.5 Ocrelizumab (RG1594) 1027.2.6 Siponimod (BAF-31
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