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PharmaMar Presents New Clinical Trials With Three Marine-Based Drugs at the American Association for Cancer Research Convention
Date:4/21/2010

l prediction to identify other tumors that are potential candidates for new preclinical and clinical trials with the compound. Phase II clinical trials are currently under way with Yondelis(R) in breast, lung and prostate cancers and pediatric tumors.

Three other trials presented at the AACR meeting provided new data on Irvalec(R), a novel marine-based synthetic depsipeptide currently in Phase II trials for lung cancer.

The first trial is evaluating the modulation of initial cytotoxic effects of Irvalec(R) using zinc and DIDS in lung cancer cells. The results suggest that plasma membrane damage caused by Irvalec(R) generates a rapid onset of hydroelectrolyte imbalance, causing severe alterations that lead to cell death by necrosis.

A second trial sheds light on the molecular mechanism associated with sensitivity and resistance to Irvalec(R). Conclusions show that primary and acquired resistance to Irvalec(R) may be associated with the expression of ErbB receptors and epithelial mesenchymaltransition markers.

A third trial shows that overexpression of ErbB2 and ErbB3 receptors does not affect sensitivity to Irvalec(R), although the receptors do suffer some changes as a result of alterations in the cell membrane produced by the compound.

Another trial suggests that PDGFRA could be a useful predictive biomarker of response to Zalypsis(R), a novel chemical entity related to the marine natural compounds jorumycin and the renieramycin family, obtained from mollusks and sponges. Zalypsis(R) is currently in Phase II trials for endometrial and cervical cancer.

About PharmaMar

PharmaMar is Grupo Zeltia's biotechnology subsidiary; it is a world leader in discovering, developing and selling marine-based drugs to treat cancer. Yondelis(R) is '/>"/>

SOURCE PharmaMar
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