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PharmaMar Presents New Clinical Trials With Three Marine-Based Drugs at the American Association for Cancer Research Convention
Date:4/21/2010

MADRID, April 21 /PRNewswire/ -- PharmaMar, a biopharmaceutical company owned by Grupo Zeltia (ZEL.MC), presented six new trials with marine-based anti-tumor drugs Yondelis(R), Zalypsis(R) and Irvalec(R) at the American Association for Cancer Research's (AACR) 101st Annual Meeting, held in Washington, D.C. from April 17-21.

The AACR meeting is the leading convention on cancer research, bringing together more than 17,000 attendees each year and covering breakthroughs in oncology and basic, clinical and epidemiological research.

Two trials provided new data on Yondelis(R) (trabectedin), a marine-based anti-tumor drug currently produced by chemical synthesis. Yondelis(R) (trabectedin) has European Commission approval for advanced and metastatic soft tissue sarcoma (STS) and for recurrent platinum-sensitive ovarian cancer in combination with Doxil/Caelyx.

Various in vitro trials have shown that trabectedin's activity depends at least partly on the nucleotide excision repair (NER) mechanism. A new trial is evaluating if the status of ERCC5 (XPG), an endonuclease-3 that plays a key role in the excision of damaged DNA, is linked to trabectedin's clinical activity in patients with advanced soft tissue sarcoma.

New data suggests that overexpression of the wild-type ERCC5 gene may be a predictor of beneficial effects of trabectedin in patients with advanced STS.

A second trial is analyzing in vitro and in vivo activity of trabectedin in a group of 67 human tumors with a view to identify a common genetic profile and pinpoint Yondelis(R)-sensitive tumors. The results of this analysis demonstrate the viability of combining experimental trials with virtua
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