Navigation Links
PharmAthene's Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimer's Disease
Date:4/9/2008

fibrils, precursors to plaque formation in the brain. These data were substantiated by transmission electron microscopy studies, which showed that rBChE dramatically suppressed the formation of fibrils, resulting in thinner and less branched filaments than would normally occur in patients with Alzheimer's disease.

More recent studies have also demonstrated that this plaque inhibitory activity is still active when peptide fragments of rBChE are used, rather than the full length protein. This may be an advantage in developing a product that can cross the blood brain barrier.

The formation of amyloid plaques in Alzheimer's disease is theorized to involve a structural transition of the amyloid beta peptide. New data generated by Dr. Soreq corroborate earlier findings, and demonstrate that both rBChE and its peptide fragments could disrupt amyloid beta organization and potentially limit its neurotoxicity.

David P. Wright, President and Chief Executive Officer of PharmAthene commented, "The early research is certainly intriguing. While we are still a long way from understanding the utility of rBChE in patients with Alzheimer's disease, our next steps will include studying rBChE in a transgenic mouse model of Alzheimer's disease to evaluate its ability to inhibit or reduce amyloid plaque formation. If the results continue to be encouraging, it may allow PharmAthene to expand applications of rBChE to additional areas beyond organophosphorous nerve agent toxicity with potentially important benefits to society. Importantly, this is consistent with our strategy of developing dual-use applications for our biodefense programs in other commercial markets."

Alzheimer's disease is a progressive neurodegenerative disease which is estimated to affect more than 4.5 million Americans. One of the hallmarks of Alzheimer's disease is the accumulation of excessive amyloid plaques in areas of the brain that control memory and cognition. Amyloid multimers are bel
'/>"/>

SOURCE PharmAthene, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. AlphaMed Pharmaceuticals Announces Breakthrough in the Development of Recombinant Alpha 1-Antitrypsin
2. Baxter Announces Recombinant Factor IX Development Program For Hemophilia B
3. CSL Behring Study in Animal Models Shows Feasibility of Developing a Half-Life Extended Recombinant FVIIa that Retains Biologic Activity
4. Inspiration Biopharmaceuticals Announces Filing of IND for Novel Recombinant Factor IX Product, IB1001, for the Treatment of Hemophilia B
5. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
6. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Review of its Phase 1/2 Trial of tgAAC94 for Rheumatoid Arthritis
7. Tart Cherries May Reduce Inflammation, Lower Risk for Type 2 Diabetes & Heart Disease
8. Shire Strives to Increase Adherence Among Chronic Kidney Disease Stage 5 Patients
9. Dutch Top Institute Allocates 150 Million Euro to R&D Projects Targeting Early Diagnosis and Treatment of Disease
10. Lilly Launches Its First Phase III Trial for Treatment of Alzheimers Disease
11. Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimers Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... YORK , July 29, 2014 /PRNewswire-iReach/ -- ... the basis of products, methods, applications, end users, ... highest growth in the microbial identification market. This ... consumable costs (per test) and the time required ... and continuous technological advancements. Furthermore, genotypic methods have ...
(Date:7/29/2014)... Holding Company (Nasdaq: ESRX ) announced 2014 ... of $515.2 million, or $0.67 per diluted share.  Adjusted ... was $1.23 for the second quarter. 1 ... with scale, alignment and innovative solutions to lower costs, manage ... stated George Paz, chairman and chief executive officer.  "We ...
(Date:7/29/2014)... , July 29, 2014 Regado Biosciences, Inc. ... on the Phase 3 clinical development of Revolixys™ Kit ... drug system, today announced that it will hold a ... 12, 2014, at 8:30 a.m. EDT to discuss its ... Interested participants and investors may access the conference ...
Breaking Medicine Technology:Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 2Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 3Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 4Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 5Microbial Identification Market Growing at 5.9% CAGR to 2019: Global Forecast in New Research Report Available at ReportsnReports.com 6Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 2Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 3Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 4Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 5Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 6Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 7Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 8Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 9Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 10Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 11Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 12Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 13Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 14Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 15Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 16Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 17Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 18Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 19Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 20Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 21Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 22Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 23Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 24Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 25Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 26Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 27Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 28Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 29Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 30Express Scripts Announces 2nd Quarter Results; Narrows 2014 Guidance Range; Maintains Mid-Point 31
(Date:7/30/2014)... 30, 2014 Today, Gen. Arthur T. ... of America (CADCA) , the nation’s leading substance abuse ... the New York Times Editorial Board’s call ... 27th. , “CADCA is disappointed in the New ... for national marijuana legalization. The move is shortsighted and ...
(Date:7/30/2014)... The Europe Phytochemicals & plant extracts market ... market in Europe with analysis and forecast of revenue. ... estimated to grow from around 710.18$ million in 2012 ... 8.4%, for the given period. , Browse through the ... report, to get an idea of the in-depth analysis ...
(Date:7/30/2014)... 30, 2014) With the advent of non-surgical modalities, ... science and researchers must work to ensure systematic ... stroke rehabilitation. A new study out today in ... in perspective and suggests that chronically stimulating premotor ... stroke motor recovery, for example by restoring balance ...
(Date:7/30/2014)... The Europe commercial aviation actuation system ... it is expected to reach $1,686.72 million by 2019 ... offers an exclusive range of opportunities and challenges which ... aviation has seen slumps in the past, yet the ... returned to its long-term growth rate of approximately 5 ...
(Date:7/30/2014)... Foot Levelers has finalized and ... by eight speakers, 29 locations throughout North America, and ... seminars cover a range of topics from billing and ... imaging. The Foot Levelers seminar series is ... courses that also offer licensing credits. , Among this ...
Breaking Medicine News(10 mins):Health News:CADCA Responds to New York Times Editorial Board's Call for Marijuana Legalization 2Health News:Europe Phytochemicals & Plant Extracts (Nutraceuticals) Market is Expected to Reach $1,150.64 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Phytochemicals & Plant Extracts (Nutraceuticals) Market is Expected to Reach $1,150.64 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Phytochemicals & Plant Extracts (Nutraceuticals) Market is Expected to Reach $1,150.64 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Phytochemicals & Plant Extracts (Nutraceuticals) Market is Expected to Reach $1,150.64 Million in 2018 - New Report by MicroMarket Monitor 5Health News:Neuro researchers advocate for a shift in thinking for stroke rehabilitation 2Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 2Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 3Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 4Health News:Foot Levelers Announces 2014 Fall Seminars Series Schedule 2
... 22 (HealthDay News) -- Does your teen often disagree with your ... knows you,re wrong? Is your teen able to make well-reasoned, albeit ... cleaning the bedroom? Their assertiveness might be trying, but there,s ... up for their views in family discussions are better at standing ...
... 22, 2011) - Check-list for a healthy life: ... Oops! You forgot something up-to-date immunizations. ... vaccine-preventable diseases, according to Dr. Vivien Brown, an adjunct ... of Medicine who lectures extensively to doctors and other ...
... , Hamilton, ON (Dec. 22, 2011) - McMaster University researchers ... (HRT) is associated with breast cancer globally. This study comes ... this medication to control hot flashes and other symptoms of ... U.S. Women,s Health Initiative (WHI) study of 2002 which found ...
... Mich.---Nine out of 10 city dwellers may have enough harmful ... exposure comes from leisure activities. Historically, loud workplaces ... the University of Michigan found that noise from MP3 players ... Neitzel, assistant professor in the U-M School of Public Health ...
... News) -- Life expectancy is a topic many disabled seniors ... have that discussion, a new study finds. It included ... had multiple illnesses and disabilities and lived in a community-based, ... had been diagnosed with a specific terminal illness. Interviews ...
... Spence of The University of Western Ontario and Dr. Meir ... Journal of the American Medical Association (JAMA) argues that vitamin ... Vitamin B therapy was once widely used ... acid in the bloodstream was linked to increased risk of ...
Cached Medicine News:Health News:Does Your Teen Constantly Challenge You? 2Health News:Adult immunization needs to move up the health check list 2Health News:Do you hear what I hear? Noise exposure surrounds us 2Health News:Most Sick or Disabled Seniors Want Docs to Say How Long They Have 2
Straight shafts with 1 x 2 teeth. Serrated handle with polished finish. Delicate teeth....
Straight shafts with 0.12 mm teeth and 5 mm tying platform. Serrated handle with polished finish. Manufactured in titanium....
Angled 45 degree shafts with 0.5 teeth and 6 mm tying platform. Polished finish....
Angled 45 degree shafts 8 mm long with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Medicine Products: