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PharmAthene Presents New Data for Lyophilized rPA Anthrax Vaccine Showing Enhanced Immunogenicity
Date:7/15/2010

ccine formulation may be able to provide protection against anthrax infection with fewer doses than a liquid vaccine formulation.  We will be conducting additional studies to confirm these preliminary results.  In addition, a lyophilized formulation could yield important practical advantages in the field."

Previously, the Company announced that its lyophilized rPA vaccine candidate was structurally stable and potent at various temperatures up to and including 70 degrees Celsius.  One of the goals of PharmAthene's rPA program is to develop a stable cold-chain-free vaccine, which could be stored and distributed at room temperature -- an important advantage for deployment in the civilian Strategic National Stockpile.

The Institute of Medicine has declared an urgent need to develop and stockpile next generation anthrax vaccines employing modern vaccine technology, which offer the potential for improved safety, convenience, cost-effectiveness, and more rapid immunity.   PharmAthene is committed to working with its partners in the United States government to address this need.

Funding for the lyophilized rPA vaccine program was provided under a Challenge grant (UC1 AI067223) from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.  

About Anthrax

According to the Centers for Disease Control and Prevention, anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease is contracted, but usually occur within seven days after exposure. The serious forms of human anthrax are inhalation anthrax, cutaneous anthrax, and gastrointestinal ant
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SOURCE PharmAthene, Inc.
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