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PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
Date:9/24/2008

e time treatment was initiated. The AGM model, which we have been developing with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) is believed to closely mimic the disease course of inhalational anthrax infection in humans. In this therapeutic model, treatment with Valortim(R) is begun only after anthrax toxin is first detected in the circulation. This model may provide an important improvement over existing therapeutic models for anthrax by precisely defining a standardized timing for therapeutic intervention," commented Mr. Wright.

About Valortim(R)

Valortim(R) is a fully human antibody designed to protect against inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein component known as the anthrax protective antigen of the lethal toxin complex produced by the bacterium. The anthrax protective antigen is believed to initiate the onset of the illness by attaching to cells in the infected person, and then is believed to facilitate the entry of additional destructive toxins into the cells. Valortim(R) is designed to target anthrax protective antigen and protect the cells from damage by the anthrax toxins.

About Protexia(R)

Protexia(R) is a recombinant version of human butyrylcholinesterase (BChE), a naturally occurring protein found in minute quantities in blood (2 mg/liter). BChE functions as a natural bioscavenger, like a sponge, to absorb and degrade organophosphate poisons (e.g. nerve agents) before they cause neurological damage. Protexia(R) is being developed as a pre- and post-exposure therapy for casualties on the battlefield or civilian victims of nerve agent attacks. Nerve agents belong to a class of compounds known as organophosphate (OP) agents. OP nerve agents, such as sarin gas, soman, tabun or VX, enter the blood stream via inhalation or absorption through the skin. The nerve agen
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SOURCE PharmAthene, Inc.
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