Navigation Links
PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
Date:9/24/2008

onal anthrax on or before the fifth day post-exposure. Extended time-to-death (days 6-9) was observed in 5 of the 8 Valortim(R)-treated animals that succumbed to inhalational anthrax.

An oral presentation entitled, "Valortim(R), an Anti-toxin Monoclonal Antibody, for the Treatment and Post-exposure Prophylaxis of Inhalation Anthrax," provided a summary of the Valortim(R) development program.

In the Phase I clinical study, 46 human volunteers were administered either a single dose of intravenous (IV) Valortim(R) (dose range 0.3 mg/kg-20 mg/kg) or intramuscular Valortim(R) (100mg). Valortim(R) was found to be safe and well-tolerated with no drug-related Grade 2-4 or serious adverse events reported. PK analysis demonstrated a half-life of approximately 26 days for IV administration.

Valortim(R) has been tested in both the New Zealand White (NZW) rabbit and non human primate models to evaluate its efficacy in the post-exposure prophylaxis and therapeutic settings.

In the post-exposure setting, Valortim(R) was dosed starting one hour after spore exposure. Valortim(R) protected >85% of both NZW rabbits and non human primates at doses as low as 1 mg/kg beginning one hour after exposure to spores.

In the therapeutic setting, Valortim(R) was dosed starting at fixed time points after spore exposure (24 or 48 hours in the NZW rabbit) or after first demonstrating antigenemia by a positive ECL assay (AGM). Valortim(R) protected 88% and 42% of NZW rabbits that initiated treatment at 24 and 48 hours after spore exposure, respectively. When AGMs were treated with Valortim(R) at the time of first positive ECL after spore exposure, 56% of the animals survived.

"We are very excited about the animal model data from the AGM study, which showed over 50% of Valortim(R)-treated animals survived inhalational anthrax as compared to no controls. This is especially compelling given that the toxin-releasing bacteria were present in the bloodstream at th
'/>"/>

SOURCE PharmAthene, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. PharmAthene to Webcast its Third Quarter Conference Call on November 13, 2007 at 4:30 P.M. Eastern Time
2. PharmAthenes Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimers Disease
3. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
4. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
5. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
6. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
7. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
8. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
9. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
10. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
11. Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase II Clinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism (DALM) 2007 Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... , June 2, 2015 ... (HIT) consulting firm, today announced the celebration of ... served throughout the U.S., since its inception in ... a skillful workforce in the healthcare technology industry ... with a company-wide dedication to facilitating clients, organizational ...
(Date:6/2/2015)... -- ErgoNurse, the leader in bedside safety management solutions, and Briggs ... the United States , have formalized a partnership to ... nursing markets. ... Thousands of healthcare professionals in acute ... the ErgoNurse products to stop unnecessarily utilizing their backs for ...
(Date:6/2/2015)... 2, 2015 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug ... studies performed with ORMD-0801, its orally ingestible insulin capsule ... the poster sessions in the ADA 75 th ... Boston . The poster will be attended by ...
Breaking Medicine Technology:Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 2Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 3ErgoNurse and Briggs Healthcare Positioned to Completely Eliminate the Unnecessary Cost of Healthcare-Related Back Injuries 2Oramed to Present at the American Diabetes Association 75th Scientific Sessions 2Oramed to Present at the American Diabetes Association 75th Scientific Sessions 3Oramed to Present at the American Diabetes Association 75th Scientific Sessions 4
... HistoRx, the leader in quantitative immunohistochemistry, has earned ... elements of digital microscopy standardization.  Combined with patents ... & Trademark Office advance the Company,s proprietary position ... dominant role in the industry.  ...
... Feb. 28, 2012  On February 28th, 2012, the New ... those interested in speaking at its 2012 Digital Health ... York City,s Pier Sixty. At NYeC,s ... New York City—over 600 healthcare providers, healthcare technology companies, ...
Cached Medicine Technology:HistoRx Achieves Dominant Intellectual Property Position in Standardization of Results from Digital Pathology Instruments 2HistoRx Achieves Dominant Intellectual Property Position in Standardization of Results from Digital Pathology Instruments 3Call for Speakers: New York's Digital Health Conference 2012 2
(Date:6/2/2015)... UCLA Health and Exer have completed negotiations ... expand urgent care services in Los Angeles County. ... of California Board of Regents and the Exer Board ... to purchase a minority share of four existing Exer ... and Northridge and creates opportunity to grow and develop ...
(Date:6/2/2015)... Gujarat, India (PRWEB) June 02, 2015 ... finalist in the 2015 Microsoft Worldwide Small and Midsized ... global field of top Microsoft partners for demonstrating excellence ... Microsoft technology. , “This comes as no surprise ... are recognized third year consecutively at worldwide level by ...
(Date:6/2/2015)... Grenoble, France, and Dallas, TX, USA (PRWEB) June 02, ... of innovative nano and microsystems, is deploying its growth ... healthcare applications, focusing on BioMEMS: “In Yole Développement’s May ... that the BioMEMS market will grow sharply and reach ... MEMS & Sensors at Yole Développement . , ...
(Date:6/2/2015)... MI (PRWEB) June 02, 2015 Erbelli’s ... new website to promote its handmade gourmet pizzas and ... even though the website is new, the recipes are ... since 1995. The main feature of the site is ... appetizing pictures and descriptions of all the items. You ...
(Date:6/2/2015)... HILLSBORO, OR (PRWEB) June 02, 2015 ... creator of ZOOM+ Performance Health Insurance, announced today the ... Healthy Clean White 57 - a three-in-one complete dental ... Healthy Clean Jr. for kids. Like all ZOOM+ services, ... , “Why shouldn’t the dentist office be as ...
Breaking Medicine News(10 mins):Health News:UCLA Health Partners With Exer - More Than Urgent Care 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 3Health News:Tronics Aims to Benefit from Major Growth of Sensors and Related Technologies for Healthcare Applications 2Health News:Erbelli’s of Bradenton Launches New Mobile-Friendly Website 2Health News:ZOOM+ Opens Its First On-Demand ZOOM+Smile Studio and Reinvents the Dental Exam 2
... Healthcare and Educate Patients, SAN FRANCISCO ... Inc. and,Iverson Genetic Diagnostics, Inc. today announced ... reports for individuals receiving,Iverson,s molecular-based assay for ... DNA Direct will provide a customized,web-enabled tool ...
... from the Patient Advocate,Foundation and the Commonwealth of ... Bills When Diagnosed with a Chronic,Debilitating or Life-Threatening ... The Patient,Advocate Foundation (PAF) - a national, non-profit ... thousands of patients every year,who face access to ...
... Screening for 28 Genetic, Metabolic Conditions, HARRISBURG, Pa., ... Governor Edward G. Rendell will help to improve the ... Department., By amending the Newborn Child Testing Act ... to continue to provide for screening and follow-up,services for ...
... Howard University and,CVS/pharmacy officially opened Howard University,s ... may sharpen their skills in a,practice setting, ... and,utilize state-of-the-art technology found in many pharmacies. ... laboratory, building upon the,Company,s strong partnership with ...
... Donahue Institute Reports Economic Activity Twice as Large as Reported Last ... ... 10 A collaborative of Massachusetts,leading human services associations today lauded a ... of the state,s human services industry could be as high as,$437 million, ...
... on Tuesday, July 29, 2008, Presenting at the BMO ... ... CINCINNATI, July 10 LCA-Vision Inc. (Nasdaq:,LCAV), a leading provider ... upcoming investment community events., Second Quarter 2008 Financial Results, ...
Cached Medicine News:Health News:DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results 2Health News:DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results 3Health News:1,000th Uninsured Virginia Patient Secures Access to Quality Medical Care Through Virginia Cares Uninsured Program (VCUP) 2Health News:1,000th Uninsured Virginia Patient Secures Access to Quality Medical Care Through Virginia Cares Uninsured Program (VCUP) 3Health News:New Law Signed by Governor Rendell Expands Newborn Screening in Pennsylvania 2Health News:Howard University and CVS/pharmacy Announce Ribbon Cutting for the Howard University Pharmacy Practice Laboratory 2Health News:Howard University and CVS/pharmacy Announce Ribbon Cutting for the Howard University Pharmacy Practice Laboratory 3Health News:New Study Shows Human Services Impact May Be $430 Million 2Health News:LCA-Vision Announces Upcoming Investment Community Events 2
Force 1C has a streamlined, compact design perfect for the requirements of outpatient surgery - as well as the power and performance features needed for a full range of general inpatient surgical pro...
... Isolated ESU on the market with 10,000V PTP ... that allows the surgeon to adjust power settings ... pencil. Excalibur Plus PC Patented Controlled Output Voltage ... cutting through various impedance tissues with minimal thermal ...
Diamond phaco knife keratome shaped blade straight. 3.2 mm wide....
Sabre 180, 230V, 50Hz is a powerful niche generator....
Medicine Products: