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PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
Date:9/24/2008

lementById('headline'); s.tl(this,'o',getLinkName('Company Sanpshot'));" >MEDX) is a fully human monoclonal antibody designed to treat and protect against inhalational anthrax. Highlights of the poster presentations include:

-- A study of non-pegylated recombinant BChE in a guinea pig model provides new data that suggests that the pegylated rBChE (Protexia(R)) may have efficacy as a therapeutic against nerve agent exposure.

-- A study of Valortim(R) in a primate animal model utilizing the African green monkey (AGM) shows promise as a potential therapeutic for the treatment of inhalational anthrax.

-- A summary of the Valortim(R) development program, including previously reported Phase I data demonstrating that Valortim(R) is safe and well-tolerated, with no drug-related Grade 2-4 or serious adverse events supporting the potential of Valortim(R) as a promising therapy for treatment and post-exposure prophylaxis for inhalational anthrax.

Summary of Data Presented:

Non-pegylated rBChE Findings Reported

In a poster entitled, "Recombinant Butyrylcholinesterase (rBChE) Therapy Following VX Poisoning by the Percutaneous Route: Preliminary Results from Guinea Pig Studies," investigators studied the effects of non-pegylated rBChE administered following poisoning by VX in an animal model which mimics percutaneous exposure. In this model, free agent was measured in both the dermis and blood enabling investigation of their temporal relationships. Non-pegylated rBChE significantly reduced the concentration of free VX in the blood. At 7.5 hours the cholinesterase activity of the plasma was approximately 27 fold greater than control. Additionally, brain cholinesterase levels were similar to previously published data from untreated controls suggesting that non-pegylated rBChE prevented the inhibition of these tissues by VX. The reduced concentration of circulating free VX following poisoning by the percutaneous route in animals t
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SOURCE PharmAthene, Inc.
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