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PharmAthene Develops Thermostable Lyophilized rPA Anthrax Vaccine Under a Challenge Grant From the National Institutes of Health
Date:7/8/2010

Various government agencies, as well as the Institute of Medicine, have acknowledged the urgent need to develop and stockpile next generation anthrax vaccines employing modern vaccine technology, which offer the potential for improved safety, convenience, cost-effectiveness, and more rapid immunity. PharmAthene's second generation rPA anthrax vaccine candidate, SparVax™, is being developed to fulfill these requirements.  

Mr. Richman continued, "As we focus on meeting the needs of our customer today with the development of improved, second generation vaccines, we are also working concomitantly to innovate the next generation of anthrax vaccines that will deliver even greater benefit to our nation and its citizens.  One of the goals of our rPA program is to develop a stable cold-chain-free vaccine, which could be stored and distributed at room temperature – an important advantage for deployment in the civilian Strategic National Stockpile.  Although at an earlier stage of development, a lyophilized formulation of rPA could meet the requirements for a cold-chain-free vaccine and we are enthusiastic about the prospects for this program."

The Company has recently achieved an important milestone in its NIH sponsored lyophilized rPA program and completed the manufacture of approximately 14,000 doses of lyophilized rPA vaccine, produced under cGMP (current Good Manufacturing Practices) conditions, which is intended to be used in ongoing development work.

Funding for the lyophilized rPA vaccine program was provided under a Challenge grant (UC1 AI067223-01) from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.  

About Anthrax

According to the Centers for Disease Control and Prevention, anthrax is an acute infecti
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SOURCE PharmAthene, Inc.
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