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Pfizer to Present More Than 40 Abstracts on Pre-Clinical, Clinical and Outcomes Research at Alzheimer's Association International Conference on Alzheimer's Disease
Date:7/8/2010

Pfizer will give an oral presentation at ICAD 2010 from a Phase I study exploring the safety and pharmacokinetics of a small molecule targeting a specific member of the PDE family in healthy volunteers.

5-HT(6) receptor antagonism: Research has suggested that 5-HT(6) receptors are located abundantly in brain regions associated with cognition.  5-HT(6) receptor antagonism may modulate multiple neurotransmitter systems that potentially impact signaling and increase structural plasticity, effects that may enhance cognition.

Pfizer is presenting four posters on two 5-HT(6) receptor antagonists, including Phase I and preliminary Phase II data.

Burden of Disease and Diagnostic Improvements: Findings also will be presented by the Pfizer and Janssen Alzheimer Immunotherapy collaboration on the risk of comorbid conditions, such as seizures, stroke and Type 2 diabetes, for patients with AD; the burden of care and costs associated with AD for patients and caregivers; and attempts to improve diagnostics.

For further information on data being presented at ICAD 2010 or Pfizer's other activities at the conference, or to arrange interviews before or during the meeting, please contact Mackay Jimeson at 212-733-2324 or mackay.jimeson@pfizer.com.

About Alzheimer's Disease

Alzheimer's disease (AD), the most common form of dementia, is a progressive, degenerative brain disease that gradually destroys a person's memory and ability to learn, reason, make judgments, communicate and carry out daily activi
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SOURCE Pfizer Inc.
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