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Pfizer to Acquire FoldRx Pharmaceuticals
Date:9/1/2010

l advisor, while Mintz, Levin, Cohn, Ferris, Glovsky and Popeo P.C., served as its legal advisor.

About Transthyretin Amyloidosis (ATTR-PN)

Transthyretin (TTR) is an amyloidogenic protein secreted by the liver.  Mutations in the TTR gene have been linked to several amyloid conditions.  Deposition of TTR amyloid in the peripheral nerve tissue results in transthyretin amyloid polyneuropathy (ATTR-PN), a sensory, motor and autonomic polyneuropathy.  The disease usually begins in the third or fourth decade with symptoms of peripheral and/or autonomic neuropathy that inexorably progress to involve muscle strength with loss of ambulation.  The patient commonly experiences a profoundly diminished quality of life with a markedly reduced life expectancy (approximately 10 years from first symptom).  Liver transplantation is the only accepted treatment, but it is not uniformly effective, and is associated with significant mortality.  It is estimated that ATTR-PN affects at least 8,000 patients worldwide, the majority of whom are in the European Union.

About tafamidis

Tafamidis is a new chemical entity, first-in-class, oral, disease-modifying agent that stabilizes the protein transthyretin (TTR) and prevents dissociation of the tetramer, the rate-limiting step in TTR amyloidosis.  Tafamidis has orphan drug designation for ATTR-PN in both the U.S. and European Union (EU) and Fast Track designation in the U.S.  FoldRx completed a 128 patient, international, multicenter Phase II/III clinical study of tafamidis for the treatment of ATTR-PN along with additional Phase 2 and 3 trials.

Pfizer Inc: Working together for a healthier world™

At Pfizer, we apply science and our global resources to improve health and well-being at every stage of life.  We strive to set the standard for quality, safety and value in the discovery, development and manufacturing of medicines for p
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