Navigation Links
Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimer's Disease
Date:4/15/2009

--New 12-month study broadens Phase 3 clinical program to further evaluate the benefits of Dimebon in Alzheimer's Disease--

NEW YORK and SAN FRANCISCO, April 15 /PRNewswire-FirstCall/ -- Pfizer (NYSE: PFE) and Medivation, Inc. (Nasdaq: MDVN) today announced the initiation of a 12-month, Phase 3 clinical trial of the investigational drug Dimebon. The study, known as CONCERT, is designed to evaluate the safety and efficacy of Dimebon when added to ongoing treatment with donepezil HCI tablets, the leading Alzheimer's disease (AD) medication worldwide, in patients with mild-to-moderate AD.

The CONCERT study is part of a broad, Phase 3 clinical development program for Dimebon. The study builds on data from a small-scale safety and tolerability trial of Dimebon added to donepezil, which found the combination to be well tolerated. CONCERT is designed to complement previous and ongoing studies by further evaluating the efficacy of Dimebon. The Phase 3 program also includes the confirmatory 6-month CONNECTION study, which is designed to evaluate the safety and efficacy of Dimebon monotherapy in patients with mild-to-moderate AD and builds on results of the first pivotal trial of Dimebon in AD.

"Due to the complexity of Alzheimer's disease, the condition often requires combination treatment to help relieve symptoms and slow disease progression," said Bengt Winblad, professor of geriatrics, Karolinska Institute. "The CONCERT trial will explore the potential additive effects of Dimebon to ongoing donepezil therapy, two drugs thought to have different mechanisms of action. We believe this trial may serve to demonstrate the potential of Dimebon in AD."

Dimebon is an investigational compound cur
'/>"/>

SOURCE Pfizer Inc; Medivation, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Pfizer Contributes Critical Data to URMC Drug Safety Initiative
2. Medarex Receives Milestone Payment from Pfizer for Investigational New Drug Application Filing
3. Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
4. Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema
5. MannKind Addresses Pfizers Announcement Regarding Exubera
6. Tacere Therapeutics Enters Collaboration and License Agreement With Pfizer To Develop and Commercialize RNAi Hepatitis C Drug
7. NicOx Announces Pfizer Initiates Phase 2 Clinical Development for PF-03187207 in Japan
8. Rigel Announces Initiation of Phase 1 Clinical Trial of R343 for Allergic Asthma by its Partner Pfizer
9. Coley Pharmaceutical Group and Pfizer Nominate Additional Anti-Cancer Compound for Clinical Development
10. Kosans Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase 1 Clinical Trial in Gastroesophageal Reflux Disease
11. Wyeths Torisel and Roche/Genentechs Avastin Will Challenge Pfizers Sutent to Become the Clinical Gold Standard for Treatment of Metastatic Renal Cell Carcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015  MedScope ( www.medscope.org ), the leading ... a 2015 Connected World magazine Connected World ... (mPERS), that can be used anywhere, anytime. The nomination ... In nominating MedScope, Landon Garner , ...
(Date:1/23/2015)... 2015  Pete Rose, baseball,s all-time hits leader, is the new ... Myoflex, Ducere Pharma has announced. "Pete,s a Hall ... have him on board with Myoflex," said Ducere Pharma Chief ... player who is known across all generations. The passion and ...
(Date:1/23/2015)... 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), announced that ... of Lixte,s lead compound, LB‑100, is being conducted, has been ... S. Kovach , M.D., the founder and President of Lixte, ... at a single site. Accrual of patients, however, was slower ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Pete Rose bets on Myoflex to relieve aches and pains 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3
(Date:1/22/2015)... (PRWEB) January 22, 2015 Liberty University has ... (M.A.) program from the Council for Accreditation of ... part of Liberty’s Center for Counseling & Family Studies ... dean of the university’s new School of Behavioral Sciences. Prior ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Padre Murphy's and ... supporter of Pro Player Health Alliance (PPHA). The ... Murphy's in getting everyone, including NFL greats, treated for obstructive ... the leading groups supporting the cause in the valley. The ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... makers of TYLENOL(r) Warming Liquids have set out to warm up chilly Boston bus riders by heating ... can be found at the following locations: , , , ... , 510 Boylston Square @ Clarendon Street , ... 333 Massachusetts Avenue @ Huntingdon , , , ...
... cognition tests, study found , , MONDAY, Jan. 26 (HealthDay News) ... glucose (sugar) levels may be linked to lower brain function, ... with higher levels of hemoglobin A1C (a measure of average ... worse results while doing cognitive tasks that tested memory, speed ...
... under age of 4 months most susceptible, analysis finds , , ... of sudden infant death syndrome (SIDS) in the United States ... in bed has quadrupled, a new study reports. , Such ... than 4 months, according to the study, published in the ...
... serious injuries from ,extreme, winter sports by following these ... many thrill-seekers, extreme ("x-treme") sports can be a fun ... winter months. Recently televised events such as the X ... including downhill ski racing and jumping, snowboarding, snowmobiling, snow ...
... Brighter smiles await,children in Georgia as the Colgate-Palmolive Company ... to the Smyrna and Marietta Big,Lots stores on Saturday, ... http://www.newscom.com/cgi-bin/prnh/20011026/BIGLOTSLOGO ) , The ... and its team,of dental professionals will provide free dental ...
... (OTC Bulletin Board: SCIE), a San Diego-based medical device ... its business.Jim Hitchin, SpectraScience,s CEO, said, "Despite a challenging ... business fronts. We understand, however, that amidst the widespread ... our shareholders with a greater level of knowledge about ...
Cached Medicine News:Health News:It's Cold Outside! Warm Up in Select Downtown Boston Heated Bus Shelters Courtesy of TYLENOL(r) Warming Liquids 2Health News:Higher Blood Sugar Could Impair Thinking 2Health News:More Accidental Infant Deaths Blamed on Suffocation in Bed 2Health News:More Accidental Infant Deaths Blamed on Suffocation in Bed 3Health News:More Accidental Infant Deaths Blamed on Suffocation in Bed 4Health News:'X-Tremely' Dangerous Sports 2Health News:'X-Tremely' Dangerous Sports 3Health News:Colgate's Bright Smiles, Bright Futures Program Brings Free Children's Dental Screenings to Atlanta Area Big Lots Stores 2Health News:SpectraScience Announces Business Update 2Health News:SpectraScience Announces Business Update 3
... The ProtecPoint Exit Alerting ... (e.g. patients, staff) and assets ... exit controllers placed throughout your ... exit protection, you're quickly ensured ...
... the movement of controlled substances, critical ... done. VerdaSee's "intellishelvess" are designed to ... is possible with no human intervention. ... this possible. VerdaSee Intellishelf™ product solutions ...
Agility can facilitate bed and room management through business process optimization using RFID technology. Bed and room management may be integrated with other AgileTrac products....
Assetrac allows identification, location, and protection of your assets....
Medicine Products: