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Pfizer Oncology To Present New Clinical Data Across Ten Tumor Types and Multiple Molecular Targets
Date:10/7/2010

tracerebral bleeding (including fatal outcomes) while receiving Torisel.  Live vaccinations and close contact with those who received live vaccines should be avoided.  Patients and their partners should be advised to avoid pregnancy throughout treatment and for 3 months after Torisel therapy has stopped.

The most common (incidence >/= 30 percent) adverse reactions observed with Torisel are: rash (47 percent), asthenia (51 percent), mucositis (41 percent), nausea (37 percent), edema (35 percent), and anorexia (32 percent).  The most common laboratory abnormalities (incidence >/= 30 percent) are anemia (94 percent), hyperglycemia (89 percent), hyperlipemia (87 percent, hypertriglyceridemia (83 percent), elevated alkaline phosphatase (68 percent), elevated serum creatinine (57 percent), lymphopenia (53 percent), hypophosphatemia (49 percent), thrombocytopenia (40 percent), elevated AST (38 percent), and leukopenia (32 percent). Most common grades 3/4 adverse events included asthenia (11 percent), dyspnea (9 percent), hemoglobin decreased (20 percent), lymphocytes decreased (16 percent), glucose increased (16 percent), phosphorus decreased (18 percent), and triglycerides increased (44 percent).

Strong inducers of CYP3A4/5 (e.g., dexamethasone, rifampin) and strong inhibitors of CYP3A4 (e.g., ketoconazole, atazanavir) may decrease and increase concentrations of the major metabolite of TORISEL, respectively.  If alternatives cannot be used, dose modifications of Torisel are recommended.  St. John's Wort may decrease Torisel plasma concentrations, and grapefruit juice may increase plasma concentrations of the major metabolite of Torisel, and therefore both should be avoided.  The combination of Torisel and sunitinib resulted in dose-limiting toxicity (Grade 3/4 erythematous maculopapular rash, and gout/cellulitis requiring hospitalization).

For more information on Torisel, including full prescribing information pleas
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