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Pfizer Discontinues Phase 3 Trial of SUTENT® in Advanced Castration-Resistant Prostate Cancer
Date:9/27/2010

ions.  To date, more than 91,000 patients have been treated with sunitinib worldwide.

Pfizer is evaluating the potential role of sunitinib for the adjuvant treatment of renal cell carcinoma in a Phase 3 trial.  

Healthcare professionals who are interested in learning more about Pfizer Oncology clinical trials that are open for enrollment can visit www.PfizerOncology.com/clinicaltrials.

About Prostate Cancer

Prostate cancer is one of the most common forms of cancer in men.(i)  For patients with castration resistant prostate cancer, who have progressed after treatment with docetaxel, there are limited treatment options available.

About SUTENT(®) (sunitinib malate)

SUTENT is an oral multi-kinase inhibitor approved for the treatment of advanced RCC and for the treatment of GIST after disease progression on or intolerance to imatinib mesylate.

SUTENT works by blocking multiple molecular targets implicated in the growth, proliferation and spread of cancer.  Two important SUTENT targets, vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), are expressed by many types of solid tumors and are thought to play a crucial role in angiogenesis, the process by which tumors acquire blood vessels, oxygen and nutrients needed for growth.  SUTENT also inhibits other targets important to tumor growth, including KIT, FLT3 and RET.

Important SUTENT(®) (sunitinib malate) Safety Information

Hepatotoxicity has been observed in clinical trials and post-marketing experience.  This hepatotoxicity may be severe, and deaths have been reported.  It is recommended to monitor liver function tests before initiation of treatment, during each cycle of treatment, and as clinically indicated.  SUTENT should be interrupted for Grade 3 or 4 drug-related hepatic a
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SOURCE Pfizer Inc.
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