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Pevion Mandated Patient Survey Confirms Disease Burden of Recurrent Vulvovaginal Candidiasis (RVVC) and Indicates Public Health Problem
Date:3/8/2012

ginal candidiasis (RVVC) is a common and moderate-to-severe chronic condition, which occurs in 7% of all adult women. To date, no study has been conducted to properly assess patients' QoL using validated questionnaires. The disease is characterized by the frequent recurrence of acute inflammations of the vagina and vulva, caused by an overgrowth of Candida albicans, and is defined as four or more acute episodes per year. Clinical symptoms cause extreme discomfort and pain and the quality of life (QoL) of patients is strongly impacted, both physically and psychologically.

Pevion has mandated a survey among more than 600 RVVC patients in the US and in the five largest European countries in order to assess the global QoL in a quantitative manner employing the validated EQ-5D and SF-36 scoring systems. The survey data show that the QoL is substantially diminished not only during an acute inflammatory episode, but also in the periods between recurrences. This reflects the maintained discomfort and stress in between acute episodes, which is accompanied by anxiety and depression in a large proportion of patients. The characteristics of a chronic disease are clearly given and the overall utility scores are significantly lower than the general population's reference value, and this, under the current standard of care. Moreover, the results show strong consistency between the six countries.

The survey revealed that there is a strong impact on patients' usual daily activities and work. A significant loss of productivity has been recorded, which represents a valuable economic damage.

The survey also investigated current treatment patterns among RVVC patients. In those patients who followed a long-term maintenance therapy with antifungal drugs, as recommended by guidelines from several medical societies, relapse occurred in two thirds of cases already within a few months. This low benefit explains why less than half of the patients actually receive su
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SOURCE Pevion Biotech AG
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