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Pervasis Therapeutics to Develop Novel Cell-Based Approach to Target Tumor Environment, Prevent Cancer Recurrence
Date:1/19/2011

, as we believe they significantly advance our understanding of the critical role endothelial cells play in inhibiting many of the aggressive aspects of cancer," stated Dr. Edelman, who is one of the original founders of Pervasis and a current member of the company's Board of Directors. "We believe this research will open the door to vast horizons for future research and the development of novel therapies, and we look forward to the work Pervasis is undertaking to advance these concepts to the clinical stage."PVS-30200 – Advantages over Current Cancer TherapiesMany current approaches to treating cancer are plagued by significant limitations such as high toxicity and serious side effects, and are systemic in nature, unable to locally target tumors. In addition, despite addressing the primary tumor, metastasis remains one of the most challenging aspects of treating cancer, and is a process that is often unpreventable and uncontrollable.  

PVS-30200 utilizes Pervasis' proprietary implantable material comprised of healthy allogeneic endothelial cells embedded in a polymer matrix that is delivered locally at the time of tumor excision to prevent cell-proliferation, inflammation and angiogenesis, key processes that lead to tumor growth and survival. The well-studied patented technology on which PVS-30200 is founded has a proven safety profile, as demonstrated by data from six clinical studies, and can be administered and targeted locally at the site of the tumor. A novel cell therapy approach, PVS-30200's use of allogeneic cells, as opposed to autologous cells, enables "off the shelf" administration, eliminating the challenging logistical processes that are involved with the use of autologous cells.  

"We plan to present our preclinical findings as well as the PVS-30200 technology to the oncology community as soon as possible; we believe this therapy has the potential to dramatically advance the promise of cell therapy as an innovative and v
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SOURCE Pervasis Therapeutics, Inc.
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