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Pervasis Therapeutics to Develop Novel Cell-Based Approach to Target Tumor Environment, Prevent Cancer Recurrence
Date:1/19/2011

es associated with the treatment of other serious conditions. We look forward to leveraging this body of knowledge to develop a novel therapy that could lead to a safer, more effective treatment for solid tumors, preventing cancer recurrence and improving outcomes for cancer patients."

The Role of Endothelial Cells in Regulating Cancer Cell BehaviorEndothelial cells are critical to tissue repair and health, and have a well-understood role in regulating many of the body's healing processes, including those associated with vascular repair. Endothelial cells work as the body's "police force" -- helping maintain homeostasis and control cells under a range of pathologic stresses. The research done at MIT upon which the licensed patent portfolio is based was led by Elazer Edelman, M.D., Ph.D., Professor of Health Sciences and Technology at MIT and Professor of Medicine at Harvard Medical School, and Joseph Franses, a graduate student in the MIT Division of Health Sciences and Technology. They demonstrated that endothelial cells are a critical component of the tumor cell stroma and serve a similar role in cancer biology as they do in vascular biology, regulating cancer cell behavior, and suppressing proliferation, invasiveness and inflammation.

There is growing evidence that invasive tumor growth results from communication between cancer cells and the surrounding host cell stroma. To that end, the breakthrough MIT research, which was published today in Science Translational Medicine(1), suggests that, in the tumor setting, quiescent endothelial cells are tumor-suppressive and slow the proliferation and invasiveness of cancer cells (as studied in culture and in animals), while disruption of the endothelial cells eliminates their ability to inhibit these actions that cause metastasis. Introducing exogenous functional, healthy endothelial cells to the stromal area can restore homeostasis.  

"We are highly encouraged by our initial findings
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SOURCE Pervasis Therapeutics, Inc.
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