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Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases
Date:3/20/2008

able liver metastases. Perioperative chemotherapy was found compatible with major liver surgery with operative mortality of less than one percent in both treatment arms."

The most common adverse events seen with pre-operative FOLFOX4 include: neutropenia (Grade 3/4: 18.1%), diarrhea (Grade 3: 8.2%), stomatitis/pharingitis (Grade 3: 6.4%), leucopenia (Grade 3/4: 5.9%), other neurological toxicity (Grade 3: 5.8%), and nausea (Grade 3: 3.5%). The most common adverse events seen with post-operative chemotherapy include: neutropenia (Grade 3/4: 34.8%), leucopenia (Grade 3: 12.2%), other neurological toxicity (Grade 3: 12.2%), sensory neuropathy (Grade 3: 9.6%), thrombocytopenia (Grade 3: 7.0%), infection (Grade 3: 6.0%), hepatic (Grade 3: 5.2%), diarrhea (Grade 3: 5.2%), allergy (Grade 3/4: 4.4%), nausea (Grade 3: 4.3%), dysesthesia (Grade 3: 4.3%), and febrile neutropenia (Grade 3: 3.5%). In both patient groups, operative mortality remained very low (<1%): two deaths occurred after surgery in the standard arm and one in the experimental arm. Reversible complications of surgery were more frequent among patients who had received chemotherapy before surgery.

Background on the EPOC Study

The EPOC Study is a randomized multicenter phase III Intergroup study sponsored and conducted by the EORTC (European Organization for Research and Treatment of Cancer), in collaboration with AGITG (Australasian Gastro-Intestinal Trials Group), EORTC GITCG (EORTC Gastrointestinal Tract Cancer Group), ALM-CAO (Arbeitsgruppe Lebermetastasen und-tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie), CRUK (Cancer Research UK) and FFCD (Federation de Cancerologie Digestive). The EPOC study was supported by sanofi-aventis.

The EPOC trial is among the few prospective studies that have examined the combination of chemotherapy and surgery for patients with initially resectable liver metastases from colorectal cancer. It is distinguished by its evaluation of periopera
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SOURCE sanofi-aventis
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