Navigation Links
Peregrine Pharmaceuticals Receives Approval to Conduct a Phase II Trial of Bavituximab in Patients With Non-Small Cell Lung Cancer
Date:1/22/2008

-Clinical Trial to Evaluate Anti-Tumor Activity of Bavituximab in

Combination with Carboplatin and Paclitaxel-

TUSTIN, Calif., Jan. 22 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and hepatitis C virus (HCV) infection, today announced that its Phase II clinical protocol to study bavituximab in combination with chemotherapy in patients with non-small cell lung cancer (NSCLC) has been approved by the Drug Controller General of India (DCGI). The primary objective of the multi-center clinical trial is to assess the overall tumor response rate in NSCLC patients treated with the combination of bavituximab and carboplatin plus paclitaxel.

In the trial's two-stage design, up to 21 patients with NSCLC will be enrolled initially. The study will then be expanded up to a total of 49 patients if promising results are observed in the initial cohort. Secondary objectives of the study include time to tumor progression, duration of response, overall patient survival and safety parameters. Patients may continue to receive bavituximab as long as the cancer does not progress and side effects are acceptable.

"This phase II trial represents an excellent opportunity for us to evaluate the potential activity of adding bavituximab to a standard regimen of carboplatin plus paclitaxel in NSCLC, a common and deadly cancer that still lacks effective treatment options," said Steven W. King, president and CEO of Peregrine. "With this approval in hand, we can now proceed with final preparations for the trial and look forward to study initiation in the near future."

Tumor response in this study
'/>"/>

SOURCE Peregrine Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
2. Peregrine Reports Data Showing Bavituximabs Potential to Shrink Prostate Tumors
3. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
4. Peregrine Pharmaceuticals Submits Clinical Protocol to Initiate Bavituximab Phase II Trial in Patients With Metastatic Breast Cancer
5. Peregrine Pharmaceuticals Doses First Patient in Clinical Trial of Bavituximab in HCV Patients Co-Infected With HIV
6. Peregrine Pharmaceuticals Submits Clinical Protocol for New Phase II Trial of Bavituximab in Patients With Metastatic Breast Cancer
7. New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models
8. Peregrine Announces Addition of The Johns Hopkins Hospital as Study Site for Bavituximab Trial in HCV Patients Co-Infected With HIV
9. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
10. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
11. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2008)... A study has found that ...ue for imaging the breast, is not affected by eith...o factors that limit the effectiveness of standard...will be presented today at the annual meeting of t..., , "The ability of PEM to detect cancer do...
(Date:12/1/2008)...S*BIO Pte Ltd today announced the initiation of a ...rally-active JAK2 inhibitor, in leading medical ce...athic myelofibrosis (CIMF). , , The trial ...y of SB1518 in patients with CIMF and is expected ...he study will assess the safety profile and evalua...
(Date:12/1/2008)...e is a two-way switch that, if turned off, causes ...that they lose their identity and become more like..., Dec. 1 Scientists at...ered that a certain differentiated cell type is so... constant expression of a gene called Prox1 to d...
(Date:12/1/2008)... Following a,Request fo...re an MVA-based,third generation smallpox vaccin...n behalf of the Canadian Department of National De...for the delivery of IMVAMUNE(R). , The Cana... of the,country,s bio-preparedness programme. , ...
Breaking Medicine Technology:New Mammography Technology Effective in Detecting Breast Cancer 2New Mammography Technology Effective in Detecting Breast Cancer 3New Mammography Technology Effective in Detecting Breast Cancer 4S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis 2S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis 3Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity 2Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity 3The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Country's Biological Preparedness 2The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Country's Biological Preparedness 3Pain Relief Network Sues to Halt Government Actions Taken Against Kansas Patients 12148 1Pain Relief Network Sues to Halt Government Actions Taken Against Kansas Patients 12148 2Darwin Introduces Enhancements to its Lawyers Professional Liability Insurance Policy Including Privacy Wrongful Acts and More 12143 1Darwin Introduces Enhancements to its Lawyers Professional Liability Insurance Policy Including Privacy Wrongful Acts and More 12143 2Darwin Introduces Enhancements to its Lawyers Professional Liability Insurance Policy Including Privacy Wrongful Acts and More 12143 3Edwards Lifesciences Announces Organizational Changes 3356 1Edwards Lifesciences Announces Organizational Changes 3356 2Research uncovers the social dynamics of yellow jackets 2253 1Research uncovers the social dynamics of yellow jackets 2253 2Research uncovers the social dynamics of yellow jackets 2253 3Research uncovers the social dynamics of yellow jackets 2253 4
(Date:12/1/2008)...END, Ind., Dec. 2 Patient satisfac...are on the rise according to a new report,from Pr...lse Report: Patient,Perspectives on American Heal...ies as a driver for improvement in patient service...2 million patients treated at more than,1,200 out...
(Date:12/1/2008)...IS, Dec. 2 While many Am...mic challenges including rising costs of,basic ne...ress Scripts,(Nasdaq: ESRX ) has expanded Rx Ou...rescription medicines. , (Logo: http://ww...LOGO ) , Lower-income consumers can now rec...
(Date:12/1/2008)...GO New research reveals that computed tomography ...py, has the potential to screen for two diseases a...which commonly affect adults over age 50. Results ... meeting of the Radiological Society of North Amer... to screening for colorectal cancer, we were able ...
(Date:12/1/2008)...k Warren Presents Award, Engages with President on...Home and Abroad During Saddleback Civil Forum on G...wire/ -- President George W. Bush was honored on t...the "International Medal of PEACE" given by Dr. Ri...during the Saddleback Civil Forum on Global Health...
Breaking Medicine News(10 mins):Health News:Outpatient Service Facilities Face Increasing Competition - Patient Perceptions More Important Than Ever 2Health News:Amid Economic Crisis, Express Scripts Offers Easy and Affordable Way for Lower-Income Consumers to Get Six-Month Supply of Prescription Medicines 2Health News:Amid Economic Crisis, Express Scripts Offers Easy and Affordable Way for Lower-Income Consumers to Get Six-Month Supply of Prescription Medicines 3Health News:Amid Economic Crisis, Express Scripts Offers Easy and Affordable Way for Lower-Income Consumers to Get Six-Month Supply of Prescription Medicines 4Health News:CT colonography offers 1-stop screening for cancer and osteoporosis 2Health News:President George W. Bush Receives 'International Medal of PEACE' That Coincides With PEPFAR Milestone on World Aids Day: 2Health News:President George W. Bush Receives 'International Medal of PEACE' That Coincides With PEPFAR Milestone on World Aids Day: 3Health News:President George W. Bush Receives 'International Medal of PEACE' That Coincides With PEPFAR Milestone on World Aids Day: 4Health News:President George W. Bush Receives 'International Medal of PEACE' That Coincides With PEPFAR Milestone on World Aids Day: 5
... scientists have successfully converted human embr...e that in future, replacement cartilage could be g...and medical // problems, including sports injuries... replacements, and even for cosmetic and reconstru...
...nts in the United Kingdom may be at a high risk of...nducted by a team of researchers randomly on 250 G...eir // patients were overdosing on vitamins and re...e placing upon their body. A large number of pati...
...are developing tests that can identify the beginni...signs of the disease emerge. The researchers, who...annual meeting of the Society for Neuroscience in ...hem to single out people who went on to develop th...
...illicit use of drugs is on the rise in England, ac...0 admissions to the emergency department each year...with // patients visiting the emergency department...The doctor in charge of emergency care was also as...
Other Medicine News:Health News:Another Potential Of Stem Cells Discovered: Used For Growing Cartilage 2Health News:Vitamin Abuse Syndrome In the UK 2Health News:Diagnosis of Alzheimer's years before clinical signs emerge 2
Nitinol Flat Wire Basket
A breakaway microwell EIA for the detection of toxins produced by Enterohemorrhagic E. coli
For presumptive identification of Escherichia coli using enzyme technology. Tests: Indole, MUG
A single tube that performs two rapid tests for E. coli from culture. ColiScreen™ combines both the indole test with the glucuronidase test to increase the specificity.
Medicine Products: