Navigation Links
Pepscan Therapeutics Presents Protein Mimicry Platform for the Discovery of anti-GPCR Antibodies at International Antibody Conference
Date:12/6/2011

SAN DIEGO, December 6, 2011 /PRNewswire/ --

Speaking today at the plenary session of the IBC's International Antibody Conference in San Diego, Dr. Klaus Schwamborn, CDO of Pepscan Therapeutics, presented Pepscan's protein mimicry platform for the discovery of therapeutic antibodies.

In his presentation 'CLIPS meets GPCRs' Dr. Schwamborn introduced the CLIPS technology and the most recent developments of immunogen design. He showed data demonstrating that Pepscan's synthetic immunogens induce potent antibodies against GPCRs and therefore are able to mimic the native receptor. Resulting antibodies do not only bind strongly to the native receptor, but also show functionality with neutralizing activity in different cell based assays. Pepscan's approach was applied to different targets, supporting the concept of a generic platform for antibody generation for any given GPCR.

Monoclonal antibody therapy is very successful and has major advantages compared to small molecule therapy. However, it is very difficult to generate monoclonal antibodies for certain important drug targets, due to technical constraints, and so far no generic approach has been documented. This is in particular valid for G-protein coupled receptors (GPCR's), for which no FDA approved antibody exists. Over the last years, Pepscan Therapeutics has validated and optimized its CLIPS technology which enables the design and synthesis of conformationally stabilized peptides with a well-defined 3D-structure, resembling the native functional protein surface. New immunogen design strategies were established which allow grafting extracellular domains of any given GPCR onto a synthetic template, mimicking the native receptor structure in an optimal way.

The platform provides a systematic and efficient way of making synthetic immunogens which induce antibodies against the native target. With these immunogens, monoclonal antibodies can be generated by using common antibody technologies
'/>"/>

SOURCE Pepscan Therapeutics BV
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Pepscan Therapeutics Strengthens Management Team
2. ViroPharma and Halozyme Therapeutics Announce Positive Data From Initial Phase 2 Assessment of Subcutaneous Cinryze® (C1 esterase inhibitor [human]) with Hyaluronidase (rHuPH20)
3. Echo Therapeutics Announces Pricing of $5.4 Million Registered Direct Equity Financing
4. FDA Sets April 24, 2012 as PDUFA Goal Date for Cell Therapeutics Resubmitted Pixantrone New Drug Application
5. GiiResearch.com: Polycystic Ovarian Syndrome (PCOS) Therapeutics - Market to Witness Static Growth Until 2018
6. Novelos Therapeutics Prices $5.9 Million Public Offering
7. Unigenes Proprietary Peptelligence™ Platform Used to Commence Cara Therapeutics Phase 1 Clinical Trial of Oral Novel Peripherally-Acting Kappa Opioid Agonist
8. Antiviral Therapeutics - Technologies, Markets and Companies
9. Pain Management Therapeutics Market to 2017 - Price Competition to Intensify Following Patent Expiries of Lyrica and Cymbalta
10. Cara Therapeutics Initiates Phase I Study with Oral Formulation of Novel Peripherally-Acting Kappa Opioid Agonist
11. Amsterdam Molecular Therapeutics Receives Orphan Designation in the European Union for Hemophilia B Gene Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/9q4d5d/veterinary_ ) has ... Vaccines Market by Product, Diseases & Technology - Global ... The global animal vaccines market is poised to ... 2015, at a CAGR of 5.5% from 2015 to ... growing prevalence of animal diseases, increasing incidences of zoonotic ...
(Date:7/2/2015)... LONDON , July 2, 2015 ... commitment to improving access to HIV treatments   ... a strategic manufacturing agreement to enable production in ... additional source of the dolutegravir active pharmaceutical ingredient (API), and ... the finished product (dolutegravir 50mg, marketed under the name Tivicay®) ...
(Date:7/1/2015)... CENTENNIAL, Colo. , July 1, 2015 /PRNewswire/ ... leader in implantable hearing solutions, announced today the ... the Cochlear™ Nucleus® Profile™ Implant with Slim Straight ... experience and developed in close collaboration with the ... thinnest cochlear implant platform designed to provide the ...
Breaking Medicine Technology:Veterinary / Animal Vaccines Market 2015 - Global Forecast to 2020 for the $7.19 Billion Industry 2ViiV Healthcare and Desano Pharmaceuticals' Manufacturing Agreement Will Allow Competitive Supply of Dolutegravir in China and Several Developing Countries 2ViiV Healthcare and Desano Pharmaceuticals' Manufacturing Agreement Will Allow Competitive Supply of Dolutegravir in China and Several Developing Countries 3ViiV Healthcare and Desano Pharmaceuticals' Manufacturing Agreement Will Allow Competitive Supply of Dolutegravir in China and Several Developing Countries 4ViiV Healthcare and Desano Pharmaceuticals' Manufacturing Agreement Will Allow Competitive Supply of Dolutegravir in China and Several Developing Countries 5ViiV Healthcare and Desano Pharmaceuticals' Manufacturing Agreement Will Allow Competitive Supply of Dolutegravir in China and Several Developing Countries 6Cochlear Combines the World's Thinnest Cochlear Implant Platform with the Industry's Thinnest Full Length Electrode 2Cochlear Combines the World's Thinnest Cochlear Implant Platform with the Industry's Thinnest Full Length Electrode 3
(Date:7/2/2015)... New York, NY (PRWEB) , ... July 02, ... ... York City for Carpal Tunnel treatment and wrist pain treatment. Dr. Lev Kalika, ... – NYDNRehab – and a leading international authority on the conservative treatment of ...
(Date:7/2/2015)... ... 02, 2015 , ... Scientists at the University of ... five federal grants to study a group of related mosquito-borne viruses. The ultimate ... The research will be conducted in the Regional Biocontainment Laboratory (RBL) at Pitt, ...
(Date:7/2/2015)... ... July 02, 2015 , ... eHuman ... a new release of their flagship product, 3D Tooth Atlas, version 7.6. This ... section and new tutorial videos. This latest release of the 3D Tooth Atlas ...
(Date:7/2/2015)... Kan. (PRWEB) , ... July 02, 2015 , ... ... dedicated exclusively to healthcare providers, has been retained to lead a national ... of the top executive search firms in the healthcare industry, B. E. Smith ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... After conducting ... Smith, Yuma Regional Medical Center in Yuma, Ariz., has hired Robert Trenschel, ... in healthcare and medical management, Dr. Trenschel will assume his new duties at Yuma ...
Breaking Medicine News(10 mins):Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 2Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 3Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 4Health News:Mosquito-Borne Viruses Subject of $4M in Federal Grants to Scientists in Pitt’s Center for Vaccine Research 2Health News:Mosquito-Borne Viruses Subject of $4M in Federal Grants to Scientists in Pitt’s Center for Vaccine Research 3Health News:Mosquito-Borne Viruses Subject of $4M in Federal Grants to Scientists in Pitt’s Center for Vaccine Research 4Health News:eHuman Digital Anatomy Releases 3D Tooth Atlas version 7.6 2Health News:Indiana Blood Center Retains B. E. Smith to Recruit New Chief Executive Officer 2Health News:Indiana Blood Center Retains B. E. Smith to Recruit New Chief Executive Officer 3Health News:Yuma Regional Medical Center Hires New Chief Executive Officer 2Health News:Yuma Regional Medical Center Hires New Chief Executive Officer 3
... , Nurtur Receives ... Nov. 23 The Population Health Impact Institute (PHII), a ... of Directors has approved the Healthcare Transparency Accreditation Program, v ... life, health, and wellness company based in Farmington, CT is ...
... than most friends, relatives or even healthcare professionals realise, according ... issue of the UK-based Journal of Advanced Nursing . ... had undergone surgery in the last year, together with 105 ... years at the Vanderbilt Transplant Center in Tennessee, USA. They ...
... ... Compliance Requirements and Automate Billing, Claims, Enrollment and Eligibility, , ... (PRWEB) November 23, 2009 ... announced today the launch of new products within its healthcare integration suite, designed ...
... both increased risk eightfold , MONDAY, Nov. 23 (HealthDay ... who were exposed to lead have more than double ... other children, new research shows. , And with exposure ... ADHD soared. Children whose mothers smoked during pregnancy and ...
... , SANTA CLARA, Calif., Nov. 23 NewCardio, Inc., (OTC ... CEO, Dr. Branislav Vajdic, and CFO, Richard Brounstein, will present at ... 4:30 PM PST at the Luxe Sunset Hotel in Los Angeles. ... December 2nd and Thursday, December 3rd. Please contact Brett Aimee ...
... ... as Best New Technology Provider for its QlikView Business Intelligence Software , ... Radnor, PA ... company, today announced that it was recognized with the Healthcare IT Innovation™ Award ...
Cached Medicine News:Health News:Population Health Impact Institute Launches Healthcare Transparency Accreditation Program(TM) 2Health News:Population Health Impact Institute Launches Healthcare Transparency Accreditation Program(TM) 3Health News:Drug side effects a key factor in reduced quality of life for kidney transplant patients 2Health News:Drug side effects a key factor in reduced quality of life for kidney transplant patients 3Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 2Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 3Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 4Health News:Smoking During Pregnancy, Lead Exposure Raise ADHD Risk in Kids 2Health News:Smoking During Pregnancy, Lead Exposure Raise ADHD Risk in Kids 3Health News:NewCardio, Inc. to Present at 2nd Annual LD MICRO Conference 2Health News:NewCardio, Inc. to Present at 2nd Annual LD MICRO Conference 3Health News:QlikTech Wins Healthcare IT Innovation™ Award 2Health News:QlikTech Wins Healthcare IT Innovation™ Award 3Health News:QlikTech Wins Healthcare IT Innovation™ Award 4
... a simultaneous vision lens with ... a series of front and ... Gp delivers up to +3.00 ... multi-aspheric center-distance design works in ...
Ophthalmic surgery stretcher. Designed for exceptional surgeon access, ideal for either superior or temporal approach....
... a staining solution for cataract surgery. ... performing a safe phaco-emulsification procedure. Inadequate ... may result in an incomplete capsulorhexis, ... radial capsule tears and associated complications. ...
Blanket protection against heavier bleeding....
Medicine Products: