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People at 'Intermediate Risk' of Heart Disease With Elevated hsCRP Benefit From Statin Therapy Even if Cholesterol Levels are Normal
Date:8/24/2010

DALLAS, Aug. 24 /PRNewswire-USNewswire/ -- Women and men with a 10-year cardiovascular disease risk of 5 percent or more and normal cholesterol levels but high levels of hsCRP, a protein associated with inflammation, could reduce their risk substantially with statin therapy, according to new research.

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The study, published in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, is a new analysis of data from the randomized, placebo-controlled, double blind Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). The study included men age 50 yrs or older and women age 60 yrs or older.

For patients with elevated high sensitivity C-reactive protein (hsCRP) – a protein associated with systemic inflammation – the study found that taking cholesterol-lowering statin drugs could:

  • reduce the relative risk of cardiovascular disease (CVD) by 45 percent for people estimated to have a 10-year CVD risk of 5 percent to 10 percent ; and
  • reduce the relative risk by 49 percent among those with an estimated 11 percent to 20 percent 10-year risk.

    • "These data demonstrate that women and men with elevated hsCRP who are otherwise at 5 percent to 20 percent 10-year risk had substantive risk reductions with statin therapy even though they are currently outside United States treatment guidelines," said Paul Ridker, M.D., lead study author and director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital, Boston, Mass.  Ridker is also principal investigator of JUPITER.

    People with a 10-year risk of less than 5 percent did not have a stat
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    SOURCE American Heart Association
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