Navigation Links
Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis
Date:7/1/2008

e there is no cure for JIA, medicines and physical therapy can help maintain movement and reduce swelling and pain. Researchers have previously identified seven subtypes of JIA.

"We think this finding may be a clue to the specific disease pathway that leads to arthritis," said Behrens, a pediatric rheumatologist at Children's Hospital. "We currently use medicines called tumor necrosis factor blockers to treat children with JIA. However, not all children respond to these drugs, and other children may develop severe allergic reactions and other side effects. If we can fully identify all the genes that interact with environmental risk factors, we might develop more targeted treatments with fewer side effects."

"The high-resolution genome-wide association approach has very markedly enhanced our ability to identify disease genes in complex disorders such as JIA, and what is remarkable about this discovery is that it appears there may be a common genetic factor predisposing to all seven forms of the disease," said Dr. Hakonarson.

The study was supported by an Institutional Research Development Award from Children's Hospital and development research awards from the Cotswold Foundation, the Nickolett Fund, and the Arthritis Foundation of Eastern Pennsylvania.

Other authors are Jonathan P. Bradfield, B.S.; Cecilia E. Kim; LeKenya Linton, R.N., A.S.; Tracy Casalunovo, M.S.; Edward C. Frackelton, B.A.; Erin Santa B.A.; F. George Otieno, M.S.; Joseph T. Glessner, M.S.; Rosetta M. Chiavacci, B.S.N., and Struan F.A. Grant, Ph.D. All are from the Children's Hospital of Philadelphia.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many d
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Childrens Brain Tumor Foundations Tissue Bank Consortium May Solve Dire Problem in Pediatric Cancer Research
2. Anesiva Announces Publication of Phase 3 Zingo(TM) Data in the Journal Pediatrics
3. Phase 3 Data Regarding Anti-RSV Antibody To Be Presented at Pediatric Academic Societies (PAS) Annual Meeting
4. New Research for Mechanical Support Devices in Pediatrics to Be Released at International Heart and Lung Transplant Meeting
5. MAP Pharmaceuticals Reports Positive Results From Comparative Pharmacokinetic Trial for its Pediatric Asthma Product Candidate
6. U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for the Acute Treatment of Manic and Mixed Episodes Associated With Bipolar I Disorder in Pediatric Patients (10 to 17 Years of Age)
7. Curemark Appoints Preeminent Pediatrics Gastroenterologist
8. Pediatric Pulmonary Expert Comments on Study of Lung Transplants for Cystic Fibrosis
9. MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV
10. Large Controlled Trial of Widely Used Mood Stabilizers Demonstrates Efficacy in Pediatric Bipolar Disorder
11. UPDATE: New Report by Pediatricians Finds Gaps in Preparing to Protect Kids From Pandemic Flu, Offers Recommendations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
(Date:9/19/2014)... Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical company ... in the U.S. and XIAPEX ® in the ... will present a corporate overview at the 21 st ... The presentation will take place on Friday, September 26, ... in New York, NY . A live ...
(Date:9/19/2014)... VIENNA , Sept. 19, 2014 ... positive interim clinical data for its lead candidate ITCA ... diabetes patients with high baseline HbA1c levels at the ... for the Study of Diabetes (EASD). Data from the ... reduced levels of blood sugar in patients with poorly ...
Breaking Medicine Technology:Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
... General Dynamics Information Technology, a business unit of General ... a contract to support the U.S. Army Medical Department,s ... facilities and transition to newly constructed facilities. The indefinite ... by the U.S. Army Corps of Engineers, has a ...
... Oct. 12 Misonix, Inc. (Nasdaq: MSON ... medical device technology, which worldwide is used for acute ... its non-exclusive distribution arrangement in the United States with ... As a result, Misonix will assume exclusive ...
Cached Medicine Technology:General Dynamics Awarded Contract to Outfit and Transition U.S. Army Medical Facilities 2General Dynamics Awarded Contract to Outfit and Transition U.S. Army Medical Facilities 3Misonix Announces Change in Distribution of SonaStar® Surgical Aspiration System in the U.S. 2
(Date:9/19/2014)... published today in the online journal PLoS Outbreaks ... West Africa by the end of the month if ... State University and Harvard University researchers also discovered through ... significantly increased in August in Liberia and Guinea, around ... place, indicating that the mass quarantine efforts may have ...
(Date:9/19/2014)... NY (PRWEB) September 20, 2014 As summer ... Krishnan DMD in Queens, NY now reminds area patients about ... than 80% of our population affected by gum disease, there ... longer.” , For over 20 years Dr. Krishnan has treated ... Hills office location. “Most patients that come in due to ...
(Date:9/19/2014)... led by Medical College of Wisconsin (MCW) scientists has identified ... in rats, mice and in humans. The findings are published ... , Leah Solberg Woods, Ph.D., associate professor of pediatrics ... Wisconsin Research Institute, led the study and is the corresponding ... identified a gene called Tpcn2 in which a variant was ...
(Date:9/19/2014)... 19, 2014 Capital Region Periodontics ... is excited to announce the latest addition to ... gingivitis and those needing dental implants. Often referred ... treatment removes the fear factor normally associated with ... discomfort and bleeding make, this procedure a very ...
(Date:9/19/2014)... researchers say a simple test that combines thinking ... for developing Alzheimer,s disease in a person, even ... dementia., Faculty of Health Professor Lauren Sergio and ... asked the participants to complete four increasingly demanding ... computers. The test aimed at detecting the tendency ...
Breaking Medicine News(10 mins):Health News:Research predicts possible 6,800 new Ebola cases this month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 2Health News:Albany, NY Periodontist Reed Ference, DMD, Calms Fears of Patients with Gum Disease by Offering LANAP®, An Advanced, Less Invasive Treatment Solution 3Health News:Simple test can help detect Alzheimer's before dementia signs show: York U study 2
... survey conducted in US in 2002 and observed that half of ... have had previous ones earlier. ,Women who had come ... 30, were from a large family and with low income. Most ... conceived in spite of it. ,Abortions are not uncommon ...
... South Korea has caused Japan to temporarily suspend the ... around 6000 chickens have died as a result of ... outbreak have been sought from South Korea. "As a ... Korean poultry", Chief Cabinet Secretary Yasuhisa Shiozaki of Japan ...
... of botulism following cosmetic injections to the face indicates ... that resulted in toxin levels up to 40 times ... ,Botulism is a rare paralytic illness caused by ... toxin-producing strains of Clostridium baratii and Clostridium butyricum. Botulism, ...
... a cheap and simple way of cutting heart disease ... to a study by heart experts, folic acid could ... blood considered to be a cause of cardiovascular disease, ... from the London School of Medicine and Barts Hospital, ...
... Two recent articles in Science by researchers at Yale School ... the risk of developing //the aggressive 'wet' form of age-related ... people over age 50. ,AMD causes light-sensitive cells ... of central vision. Of the two forms of AMD, the ...
... for Ageing, Senator Santo Santoro, to discuss the issue of ... AMA's Federal Budget Submission 2007-08. ,The current ... difficult for GPs to provide ongoing care to residents of ... Haikerwal, said today the number of general practitioners able to ...
Cached Medicine News:Health News:Highly-Concentrated Botulinum Preparation Can Result in Severe Illness 2Health News:Highly-Concentrated Botulinum Preparation Can Result in Severe Illness 3Health News:Gene Linked With Aggressive 'Wet' Form Of AMD 2
The Wire Cutters are designed to cut Kirschner wires up to 2.5 mm diameter easily and smoothly. They are particularly useful for external fixation applications. The Wire Cutters shear fixation wires ...
The osteotome shafts are manufactured with stainless steel and are available both straight and curved in 1/4" and 1/2" sizes....
... Pulse CDC Compact Cardiac Digital Camera is a ... open, patient-friendly gantry, and provides full sized fields ... into your clinic you need a flexible system ... Find out how the Pulse reduces the ...
... is the ultimate objective of neurovascular treatment ... Detachable Coils, occlusion is only the beginning... ... intended for embolization of those intracranial aneurysms ... location, or the patient's general medical condition ...
Medicine Products: