Navigation Links
Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis
Date:7/1/2008

PHILADELPHIA, July 1 /PRNewswire-USNewswire/ -- Researchers have found that a gene region known to play a role in some varieties of adult rheumatoid arthritis is also present in all types of childhood arthritis. The researchers say the responsible gene may be a "master switch" that helps turn on the debilitating disease.

Researchers at The Children's Hospital of Philadelphia reported on the link between the gene region and juvenile idiopathic arthritis (JIA), formerly called juvenile rheumatoid arthritis. The genetic variant is on chromosome 9 in a region housing two genes, TRAF1 and C5. The TRAF1 gene codes for a protein that regulates tumor necrosis factor, a chemical strongly associated with JIA. However, the researchers say further study is needed to determine whether the TRAF1 gene or the C5 gene is altered in the disease.

The study appears in the July 2008 issue of Arthritis & Rheumatism. Lead authors are Terri H. Finkel, M.D., Ph.D.; Hakon Hakonarson, M.D. Ph.D., director of the Center for Applied Genomics; and Edward M. Behrens, M.D., all of Children's Hospital.

"There are only a few genes that may act as master switches like this to regulate autoimmune diseases," said Finkel, the chief of Rheumatology at Children's Hospital. "This switch we discovered probably has to be an 'ON' gene and when it interacts with other genes and environmental triggers, a child may get juvenile arthritis."

The study compared 67 Caucasian patients being treated for JIA to 1,952 healthy Caucasian control subjects recruited within the hospital's patient network. While the cause of JIA is unknown, results from this study back up past research that shows arthritis arises in a genetically susceptible individual due to environmental factors.

About 300,000 children in the U.S. have JIA, of which about 1,500 children are seen at Children's Hospital. JIA is the inflammation of the lining tissues of a joint and often causes stiffness and pain. Whil
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Childrens Brain Tumor Foundations Tissue Bank Consortium May Solve Dire Problem in Pediatric Cancer Research
2. Anesiva Announces Publication of Phase 3 Zingo(TM) Data in the Journal Pediatrics
3. Phase 3 Data Regarding Anti-RSV Antibody To Be Presented at Pediatric Academic Societies (PAS) Annual Meeting
4. New Research for Mechanical Support Devices in Pediatrics to Be Released at International Heart and Lung Transplant Meeting
5. MAP Pharmaceuticals Reports Positive Results From Comparative Pharmacokinetic Trial for its Pediatric Asthma Product Candidate
6. U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for the Acute Treatment of Manic and Mixed Episodes Associated With Bipolar I Disorder in Pediatric Patients (10 to 17 Years of Age)
7. Curemark Appoints Preeminent Pediatrics Gastroenterologist
8. Pediatric Pulmonary Expert Comments on Study of Lung Transplants for Cystic Fibrosis
9. MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV
10. Large Controlled Trial of Widely Used Mood Stabilizers Demonstrates Efficacy in Pediatric Bipolar Disorder
11. UPDATE: New Report by Pediatricians Finds Gaps in Preparing to Protect Kids From Pandemic Flu, Offers Recommendations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB ... composition of matter, biological targets, mechanism of action, methods ... This patent application describes a novel class ... which interfere with the basic homeostatic cellular processes in ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness & ... Center by the Medical Fitness Association, a non-profit organization ... their full potential. The Cadence Fitness & Health Center ... suburbs and second in the Chicagoland area. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
(Date:7/9/2014)... YORK (July 8, 2014) Researchers from Montefiore ... of Medicine of Yeshiva University will present new ... held July 12 July 17 in Copenhagen, Denmark. ... that could prompt transition from cognitive normality to mild ... the Einstein Aging Study , established in 1980 ...
(Date:7/9/2014)... for more than watching World Cup highlights, Brian Williams ... landing in unfortunate positions on railings. A University of ... Online Journal shows that YouTube also allows researchers, ... public on topics of skin cancer and prevention. , ... the future of how we communicate around the world," ...
(Date:7/9/2014)... Diseases (NIAID), part of the National Institutes of ... CRS3123, an investigational oral antibiotic intended to treat ... infection. CRS3123 (previously known as REP3123) is a ... sparing normal intestinal bacteria. , The Phase I ... and women ages 18 to 45 in a ...
(Date:7/9/2014)... 2014) A retrospective study conducted by researchers at ... that among adults with intellectual and developmental disabilities, the ... years receiving dental care increased. The findings, published in ... , may help improve interventions designed to address the ... The researchers reviewed the dental records of 107 patients ...
(Date:7/9/2014)... with kidney and heart disease have raised concerns about ... However, in the first study to look closely at ... at the University of Pennsylvania report that older kidney ... and cardiovascular health as very healthy older people who ... ever increasing organ transplant waitlists, the authors of the ...
Breaking Medicine News(10 mins):Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Adults with special needs see gains, challenges with long term oral care 2Health News:Adults with special needs see gains, challenges with long term oral care 3Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2
... Health Integrated, Inc., a,pioneer in health and condition ... its ground-breaking Synergy Personal Health,Management program at DMAA,s ... September 16th at Caesar,s Palace in Las,Vegas. ... a need to stay,informed of the best practices, ...
... is a prevailing issue in the United States, with ... study reveals that Pycnogenol, (pic-noj-en-all), an antioxidant plant extract ... reduces ADHD in children. The study shows Pycnogenol balances ... a decrease of ADHD. , The findings, to ...
... 12, 2007) For the first time in history, ... corals in its annual report of wildlife going extinct. ... Conservation International (CI) and implemented jointly with the IUCN ... Darwin Research Station and other regional institutions to conclude ...
... ReBuilder Medical,Technologies, Inc. today reported to its board ... base to include England, Canada, New,Zealand and Australia. ... sales began to come in as a result ... using the ReBuilder System(R). Through,word of mouth and ...
... Biomedical,Corporation (TSX-V: RBM, OTCBB: RPBIF) today announced the ... (CEO). Mr. Kay was also appointed,to the Company,s ... former President, CEO and Director of Quidel Corporation,a ... and,marketing of rapid diagnostic solutions at the point-of-care ...
... Md., Sept. 12 Since the late,1980,s, adult obesity has ... of all Americans are now overweight and over 30 percent ... to 19 are,overweight -- nearly double the rate of two ... is the Nutrition Facts Label on,food packages, according to the ...
Cached Medicine News:Health News:Health Integrated to Showcase Synergy Personal Health Management(R) at DMAA Conference 2Health News:New study: Pine bark extract reduces ADHD symptoms in children 2Health News:Corals added to IUCN Red List of Threatened Species for first time 2Health News:Corals added to IUCN Red List of Threatened Species for first time 3Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 2Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 3Health News:ReBuilder Medical Technologies, Inc. Reports International Sales Expansion 4Health News:Response Biomedical appoints S. Wayne Kay Chief Executive Officer 2Health News:Response Biomedical appoints S. Wayne Kay Chief Executive Officer 3Health News:Response Biomedical appoints S. Wayne Kay Chief Executive Officer 4Health News:FDA: Use the Nutrition Facts Label to Make Healthy Food Choices 2
... tilt, user programmable memory two position ... on both chair sides, solid cast ... Single button folding armrests and headrest, ... on both chair sides, ergonomically contoured ...
... chair for examination of the ... adjustable from 540 mm to ... an independent foot switch. The ... and incorporates a multi-adjustable headrest, ...
Heine Beta 200 Streak Retinoscope 3.5v w/Twist Lock for Welch-Allyn style handles....
Heine Beta 200 Streak Retinoscope 3.5v...
Medicine Products: