Navigation Links
Pearl Therapeutics Reports Positive Phase 2b Results of PT001 in Patients With COPD
Date:12/7/2011

REDWOOD CITY, Calif., Dec. 7, 2011 /PRNewswire/ -- Pearl Therapeutics Inc. today announced positive top-line results from a randomized, double-blind, Phase 2b, dose-ranging study of glycopyrrolate, a long-acting muscarinic agonist (LAMA) delivered twice a day (BID) via metered-dose inhaler (GP MDI; PT001) in patients with moderate-to-severe COPD. Four doses of GP MDI were compared to placebo and Atrovent® HFA Inhalation Aerosol, a short-acting muscarinic antagonist given four times a day (QID). All doses of GP MDI tested produced statistically significant improvements in lung function (FEV1 AUC 0-12)(1) compared to placebo (p<0.0001). Further, doses of PT001 were identified that were non-inferior to Atrovent HFA. PT001 was well tolerated and no safety concerns were identified. This study complements Pearl's previous assessment of PT001's clinical profile relative to well established marketed muscarinic antagonists(2), and provides additional dose ranging data for glycopyrrolate component of Pearl's LAMA/LABA combination product, PT003. Detailed results of this Phase 2b study of PT001 will be presented at a future conference.

Dr. Colin Reisner, chief medical officer and executive vice president of clinical development for Pearl Therapeutics commented, "This Phase 2b study provides important information about the safety and efficacy of GP MDI, the LAMA component of PT003, our lead combination bronchodilator candidate for the treatment of COPD. Further, the activity profile of GP MDI in this study is consistent with that observed in two previously reported studies and supports the BID dosing that we believe will provide the best symptom relief for patients with moderate-to-severe COPD."

"A significant part of the very large COPD market is driven by the use of BID LABAs and inhaled corticosteroids.  However, a rapid-acting, BID LAMA to complement
'/>"/>

SOURCE Pearl Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Pearl Therapeutics Presents New Scientific Evidence Supporting Versatility of Its Novel Cosuspension MDI Platform
2. Anthera Announces Last Patient Enrolled in PEARL-SC Study
3. Pearl Therapeutics Bronchodilator Combination PT003 Provides Superior Inspiratory Capacity Compared to Spiriva®
4. Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI
5. Pearl Therapeutics Advances Its Long-Acting Bronchodilator Combination Product Candidate into Four Additional Phase 2 Studies
6. Pearl Therapeutics Phase 2b Results Show a 50% Improvement in Lung Function with PT003 Compared to Spiriva® and Foradil® in Patients with COPD
7. Asante Solutions Receives FDA Clearance for Pearl™ Insulin Pump
8. Pearl Therapeutics Highlights Its Porous Particle Cosuspension Platform, Demonstrating Universal Applicability Across Multiple Drug Classes and Combination Products
9. Pearl Therapeutics to Present Complete PT003 Results from Phase 2b COPD Study in a Late-Breaker Session at the American Thoracic Society Annual Meeting
10. Asante Solutions, Inc. Receives CE Mark for Pearl™ Insulin Pump
11. Echo Therapeutics to Present at the Oppenheimer Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... Disorders Drug Pipeline Insight 2014" report to their offering. ... in US is one of the largest segments of pharmaceuticals ... alarming rate, while the available therapies were unable to meet ... in the market for CNS disorder, especially over the past ...
(Date:8/29/2014)... Research and Markets has announced the addition ... Pharmaceutical Equipment Market in China, 2014-2018" report to ... Forecast of Pharmaceutical Equipment Market in China ... pharmaceutical equipment industry in the aspects of current ... performance of domestic major enterprises, as well as offers ...
(Date:8/29/2014)... According to the new ... (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User (Research, ... Synthesis, NGS, DNA, RNAi) - Global Forecast to ... Market is expected to reach $1,712.1 Million by ... a CAGR of 9.8% from 2014 to 2019.. ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
... HAMILTON, N.J., Sept. 14 MedAvante, Inc., the leader ... that the U.S. Food and Drug Administration (FDA) has ... psychiatric medication including primary outcome data collected by MedAvante ... a Johnson & Johnson company, submitted the NDA for ...
... privately-held biotechnology company focused on developing a novel class ... Quinton Oswald has joined the company as Chief Executive ... experience and management expertise to the CEO role. Most ... President & Business Unit Head for the Tissue Growth ...
Cached Medicine Technology:FDA Approves NDA That Includes Psychiatric Data Collected by Centralized Raters 2FDA Approves NDA That Includes Psychiatric Data Collected by Centralized Raters 3Quinton Oswald Named Chief Executive Officer of SARcode Corporation 2Quinton Oswald Named Chief Executive Officer of SARcode Corporation 3
(Date:8/30/2014)... Acne is a common problem millions of American cope ... than a daily nuisance, for some, it can have a crippling ... even lead to dramatic mood swings and depression. , Those ... up their skin. In some cases, that can make the problem ... error, those on a quest for clearer skin can now view ...
(Date:8/30/2014)... New York, New York (PRWEB) August 30, 2014 ... and other incretin mimetic claims continue to move forward ... a statement issued by AstraZeneca PLC on July 31, ... have been named in 409 product liability claims that ... cancer. Court documents indicate that many of these claims ...
(Date:8/30/2014)... HealthDay Reporter FRIDAY, Aug. 29, ... on for broken bones or other orthopedic trauma shops around ... Less-educated patients and patients who had used narcotic painkillers ... said study lead author Dr. Brent Morris, a shoulder and ... suggests that doctors aren,t talking to one another about the ...
(Date:8/30/2014)... 30, 2014 "My wife suffered neck, ... car accident," said one of two inventors from Bethel, ... her shoulder and neck area. She tried other pillows ... and pressure, assisting in comfort and providing extra sleep." ... CRADLE to support the head, neck and back comfortably. ...
(Date:8/30/2014)... August 30, 2014 "My niece developed ... that, at any moment, her fever might get worse," ... keep me well aware of how she was doing, ... TEMP ALARM to continuously monitor a child's temperature. The ... fever. This ensures that prompt medical care can be ...
Breaking Medicine News(10 mins):Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 3Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 3
... , , , ... (Hologic or the Company) (Nasdaq: HOLX ), a ... systems and surgical products dedicated to serving the healthcare needs ... (FDA) cleared the Company,s 510K application for the MammoSite((R)) ML ...
... , NEW YORK, Sept. 5 Reporter Jim ... 5, 2009) Mr. Rutenberg accused me of making false statements, but ... statements are true. Mr. Rutenberg is the one writing falsehoods. ... are not what,s needed. The focus should be on the health ...
... ... of Hissey Kientz, LLP is warning consumers to immediately stop ... prior to a colonoscopy. In December 2008 the Food and Drug Administration ... the FDA’s warnings about the dangers of Phospho-soda and Fleet’s recall of ...
... ... winners of the 2009 research grants. This year,s grantees will explore such important ... opioids enhance migraine pain. , ... (PRWEB) September 5, 2009 -- The Migraine Research Foundation (MRF), the only ...
... WASHINGTON, Sept. 4 The California Nurses ... of Medicine for recommending strong patient safety protections for ... ongoing H1N1/swine flu pandemic--and calls on the Centers for ... , "America,s registered nurses have significant ...
... dual parents for child,s success , SATURDAY, Sept. 5 (HealthDay ... one- or two-parent household -- may help a child succeed ... findings, by an Ohio State University professor, challenge the conventional ... single parent marrying or moving in with a partner may ...
Cached Medicine News:Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 2Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 3Health News:FDA Clears Hologic's MammoSite(R) ML Radiation Therapy System for the Treatment of Early-Stage Breast Cancer 4Health News:Betsy McCaughey Addresses New York Times: Charges of Falsehoods But No Evidence 2Health News:Betsy McCaughey Addresses New York Times: Charges of Falsehoods But No Evidence 3Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 2Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 3Health News:Hissey Kientz LLP Urges Patients To Heed FDA Warning About Phospho-soda Products 4Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 2Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 3Health News:Migraine Research Foundation Announces Winners of 2009 Research Grants 4Health News:America's Registered Nurses Applaud New Institute of Medicine H1N1/Swine Flu Safety Recommendations -- and Call on CDC to Maintain Stringent Safety Guidelines 2Health News:Single Parents May Do as Well as Two: Study 2
1000 L, Racked, Pre-sterilized, 100 tips/rack Recommended for 500 and 1000 L pipettes....
300 L, Racked, Filtered, Pre-sterilized, 96 tips/rack Recommended for 250 and 300 L pipettes....
Diamond Filter Tips play a critical role in preventing aerosol-borne contamination. Also available sterilized (no need to autoclave) and certified free of detectable RNase, DNase, DNA, RNA, and prote...
... Eliminate aerosol contamination, which ... in PCR. Hydrophobic, nonwicking ... air can pass through ... in contrast to tips ...
Medicine Products: