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Pearl Therapeutics Presents New Scientific Evidence Supporting Versatility of Its Novel Cosuspension MDI Platform
Date:10/28/2011

REDWOOD CITY, Calif., Oct. 28, 2011 /PRNewswire/ -- Pearl Therapeutics Inc. presented data elucidating the robust aerosol performance and physicochemical foundations of the Company's cosuspension technology which uses spray-dried, low-density porous particles to deliver drug microcrystals via pressurized metered dose inhalers (MDIs). Two posters were presented this week at the 25th American Association of Pharmaceutical Scientists annual meeting in Washington DC.

"These results demonstrate the flexibility of Pearl's metered dose inhaler platform for multiple drugs and combinations," said Sarvajna Dwivedi, Ph.D., Pearl's cofounder and executive vice president, research and development. "The research conducted at Pearl has improved our understanding of the structure of porous particles and their constituents well beyond that of four years ago when Pearl first licensed its porous particle technology. As a result of such scientific progress, the Company has filed several new patent applications globally, which we believe will offer broad protection for our pipeline of respiratory products."

In vitro drug delivery performance data of Pearl's lead candidate for COPD, PT003, a cosuspension of formoterol fumarate (FF) and glycopyrrolate (GP), as well as a triple combination cosuspension of FF, GP and mometasone furoate (MF), an inhaled corticosteroid, were presented at the AAPS meeting, along with the results of each individual drug's cosuspension. Results demonstrate that Pearl's proprietary cosuspension technology enables consistent aerosol performance that is equivalent for all cosuspended drugs regardless of dose for mono, dual and triple combinations, without changing the nature of porous particles for each product type. Further analyses presented by Pearl scientists at AAPS show solid state structural details and thermal propertie
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SOURCE Pearl Therapeutics
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