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Pearl Therapeutics Highlights Its Porous Particle Cosuspension Platform, Demonstrating Universal Applicability Across Multiple Drug Classes and Combination Products
Date:5/5/2011

of Pearl's cosuspension platform that allows MDIs – currently used to deliver over 70% of the inhaled doses worldwide – to be developed with long-acting muscarinic antagonists (LAMA), long-acting beta-2 adrenergic receptor agonists (LABA) and inhaled corticosteroids (ICS), in their natural crystalline form.  The evidence showed that the porous particles are practically insoluble in hydrofluoroalkane (HFA) propellant, and associate with micronized drug crystals in a way that reduces the interaction between crystals and with the inhaler components.  

A supporting poster provided a comparison of dual and triple cosuspensions of the potent LAMA, glycopyrrolate with either the highly potent LABA, formoterol fumarate, or the ICS, mometasone furoate, or both formoterol fumarate and mometasone furoate.  Pearl's porous particle cosuspensions, whether formed with one, two or three of these drugs, generate highly efficient aerosols with equivalent aerodynamic particle size distribution. Moreover, they maintain long-term chemical stability within internationally accepted limits for each drug after months of storage at room temperature, confirming the continuity of product performance across various product types with Pearl's cosuspension platform over time.  

Additionally, Pearl presented evidence that the cosuspensions form quickly and can be manufactured by pressure filling into MDIs using commercially available filling equipment and standard MDI components. Various doses of single, dual and triple combination cosuspensions were produced at small scale with a process representative of commercial scale, and were found to be stable with dose-proportional and uniform aerodynamic size distribution profiles.

Dr. Dwivedi added, "The Pearl cosuspension offers consistently efficient drug delivery across drug classes, doses and product types; no detrimental physical or chemical interaction between drugs or between drugs and inhale
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SOURCE Pearl Therapeutics Inc.
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