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Pearl Therapeutics' Bronchodilator Combination PT003 Provides Superior Inspiratory Capacity Compared to Spiriva®
Date:9/26/2011

combination of glycopyrrolate and formoterol MDI (GFF MDI) demonstrates superior inspiratory capacity (IC) compared to tiotropium DPI (Tio) following 7 days dosing, in a randomized, double-blind, placebo-controlled Phase 2b study in patients with COPD"

Date & Time: Tuesday September 27, 2011; 12:50pm – 2:40pm
Thematic Poster Session: Drug delivery and pharmacokinetics II; Session 414
Title: "Glycopyrrolate MDI Demonstrates Comparable Efficacy and Safety to Tiotropium Dry Powder Inhaler in a Randomized, Double-Blind, Placebo-Controlled Phase 2b Study in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease"

Reproduction of these posters may be retrieved from the Publications page of the Pearl website.

About COPD

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable lung disease that is the fourth leading cause of death in the United States. Each year 12 million Americans are diagnosed with COPD and an additional 12 million Americans may have COPD but remain undiagnosed. Research shows that many do not get optimal treatment.

Bronchodilator medications are central to symptom management and are prescribed on an as-needed or regular basis to prevent or reduce symptoms. Long-acting inhaled bronchodilators have been shown to be most effective and convenient. Combining bronchodilators of different pharmacological classes, as recommended by The Global Initiative for Chronic Obstructive Lung Diseases (GOLD), has been shown to improve efficacy and may decrease the risk of side effects compared to increasing the dose of a single bronchodilator. As the course of COPD progresses, regular treatment with inhaled glucocorticosteroids may be added to bronchodilator treatment. Pearl is developing inhaled combination products designed
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SOURCE Pearl Therapeutics Inc.
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1. Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI
2. Pearl Therapeutics Advances Its Long-Acting Bronchodilator Combination Product Candidate into Four Additional Phase 2 Studies
3. Pearl Therapeutics Phase 2b Results Show a 50% Improvement in Lung Function with PT003 Compared to Spiriva® and Foradil® in Patients with COPD
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