Navigation Links
Pearl Therapeutics' Bronchodilator Combination PT003 Provides Superior Inspiratory Capacity Compared to Spiriva®
Date:9/26/2011

>

In this Phase 2b study, patients with moderate-to-very severe COPD were randomized to receive one of two doses of PT003, PT001, one of two doses of PT005, Spiriva, Foradil® Aerolizer® (formoterol fumarate inhalation powder), or placebo. The two doses of PT003 (72 mcg GP/9.6 mcg FF and 36 mcg GP/9.6 mcg FF) and Spiriva provided statistically significant improvements in IC compared to placebo on day one (p<0.0001 all comparisons) and on day seven (p<0.0004 all comparisons). Both doses of PT003 provided a benefit on day one relative to Spiriva, with the higher dose showing statistical difference vs Spiriva (p<0.05). Further improvement was observed with chronic dosing, with both doses of PT003 providing a statistically significant benefit on day seven pre-dose and two hours post-dose relative to Spiriva (p<0.05).

"These results provide important early evidence of the broad clinical promise inherent in Pearl's fixed-dose bronchodilator combination, PT003 for patients suffering from debilitating effects of COPD," said Chuck Bramlage, Pearl's CEO. "These results strengthen our confidence in sustaining PT003's rapid progress towards late stage clinical development in 2012."

Pearl will also present at ERS an analysis of the efficacy of the two LAMAs studied in this trial, PT001 (36 mcg, BID) and Spiriva (18 mcg, QD). Both PT001 and Spiriva were shown to provide superior bronchodilation compared to placebo, yielding mean improvements in FEV1 (AUC 0-12) of 189 mL and 195 mL, respectively (p<0.0001 for both). The difference between these values was 6 mL, demonstrating that PT001 is statistically similar (non-inferior) to Spiriva (95% confidence interval -49; 38).

Poster Details
Date & Time: Sunday, September 25, 2011; 12:50pm – 2:40pm
Thematic Poster Session: Bronchodilators in asthma and COPD; Session 96
Title: "Fixed
'/>"/>

SOURCE Pearl Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI
2. Pearl Therapeutics Advances Its Long-Acting Bronchodilator Combination Product Candidate into Four Additional Phase 2 Studies
3. Pearl Therapeutics Phase 2b Results Show a 50% Improvement in Lung Function with PT003 Compared to Spiriva® and Foradil® in Patients with COPD
4. Asante Solutions Receives FDA Clearance for Pearl™ Insulin Pump
5. Pearl Therapeutics Highlights Its Porous Particle Cosuspension Platform, Demonstrating Universal Applicability Across Multiple Drug Classes and Combination Products
6. Pearl Therapeutics to Present Complete PT003 Results from Phase 2b COPD Study in a Late-Breaker Session at the American Thoracic Society Annual Meeting
7. Asante Solutions, Inc. Receives CE Mark for Pearl™ Insulin Pump
8. Orexigen Therapeutics to Present at the JMP Securities Healthcare Conference
9. Afraxis Enters Collaboration with NIH as Part of Therapeutics for Rare and Neglected Disease Program
10. Reed V. Tuckson, M.D., Executive Vice President and Chief of Medical Affairs at UnitedHealth Group, Joins Board of Directors of Cell Therapeutics, Inc. (CTI)
11. Prime Therapeutics Launches CareCentered Contracting™ Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... , July 6, 2015  Array BioPharma Inc. ... Chief Executive Officer, Ron Squarer , will ... in New York City.  The public is welcome ... on the Array BioPharma website. Event: Cantor Fitzgerald 2015 ... 2015Time:1:00 p.m. Eastern Time Webcast: www.arraybiopharma.com About Array ...
(Date:7/6/2015)... 2015  OrthoSpace Ltd. ("OrthoSpace" or "Company") announced ... in its US Investigational Device Exemption (IDE) pivotal ... single blinded control study that compares the Company,s ... partial repair for the treatment of full thickness ... commercially available outside of the United ...
(Date:7/6/2015)... 2015 Mauna Kea Technologies ... confocal laser endomicroscopy platform, announced today it has ... Ministry of Health, Labor and Welfare (MHLW) for ... AQ-Flex 19 miniprobe.   Used during ... is comprised of a fiber-optic microscope that is ...
Breaking Medicine Technology:OrthoSpace Enrolls First Patients in US IDE Study 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3
... WIRE)--Jun 21, 2007 - BioSante,Pharmaceuticals, Inc. (AMEX:BPA) ... (WHI) Coronary Artery Calcium Study,published yesterday in ... study found that younger menopausal women (aged ... therapy had significantly less,coronary artery calcification at ...
... announced clinical,results from the first of five phase ... analogue. The 26-week study is part of,the LEAD(TM) ... 581 patients with type 2 diabetes inadequately,controlled by ... drugs:,metformin and a sulfonylurea (glimepiride). All patients in ...
Cached Medicine Technology:New Analysis of WHI Data Shows Reduced Levels of Coronary Artery,Calcification, a Predictor of Cardiovascular Events, in Women aged,50-59 taking Estrogen Therapy 2New Analysis of WHI Data Shows Reduced Levels of Coronary Artery,Calcification, a Predictor of Cardiovascular Events, in Women aged,50-59 taking Estrogen Therapy 3New Analysis of WHI Data Shows Reduced Levels of Coronary Artery,Calcification, a Predictor of Cardiovascular Events, in Women aged,50-59 taking Estrogen Therapy 4Liraglutide provides significantly better glucose control than,insulin glargine in phase 3 study 2Liraglutide provides significantly better glucose control than,insulin glargine in phase 3 study 3Liraglutide provides significantly better glucose control than,insulin glargine in phase 3 study 4
(Date:7/6/2015)... ... July 06, 2015 , ... Understanding ... services and ADVOCATE is leading the transition. ADVOCATE, the only 100% radiology, revenue ... Top 10 Tips for ICD-10. The ten tips are timely and relevant guidelines ...
(Date:7/6/2015)... ... July 06, 2015 , ... Longevity, the highest ... with Woodbridge Walk-In Urgent Care to offer on-site health screenings. These ultrasound screenings ... Screenings are affordable and accurate and run about an hour long with same ...
(Date:7/6/2015)... ... July 06, 2015 , ... Seedstock today announced Pierre Sleiman, ... at the 4th Annual Seedstock Sustainable Agriculture Conference – “Innovation and the Small Farmer” ... held at the University of California-San Diego, will explore solutions and methodologies that small ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... ... area, Carlson & Associates has once again teamed up with Family Emergency Shelter ... families to move toward self-sufficiency. FESCO was created especially to provide emergency services ...
(Date:7/6/2015)... ... July 06, 2015 , ... In a split second, ... to reduce their risk of having a fracture through the bone health screenings conducted ... Day. , “We are participating because our residents need this information to remain independent ...
Breaking Medicine News(10 mins):Health News:ADVOCATE Takes the Lead to Ensure ICD-10 Success: “Top 10 Tips for ICD-10” 2Health News:Woodbridge Walk-In Offers Affordable Early Detection Health Screenings Through Longevity 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4Health News:Carlson & Associates Insurance Agency and Nonprofit Family Emergency Shelter Coalition (FESCO) Initiate New Charity Campaign in Alameda County, CA to Provide for Homeless 2Health News:Carlson & Associates Insurance Agency and Nonprofit Family Emergency Shelter Coalition (FESCO) Initiate New Charity Campaign in Alameda County, CA to Provide for Homeless 3Health News:National Bone Health Screening and Awareness Day 2
... NEW YORK, Sept. 3 Reportlinker.com announces that a new market ... U.S. Markets for Addiction and Substance Abuse Treatment ... , , INTRODUCTION , , STUDY ... details the complicated world of substance abuse. The increased prevalence of substance ...
... , NEW YORK, Sept. 3 , , ... its catalogue. , , Healthcare Information Technology ... This Report: , , , ... health care IT technologies , Forecasts trends and ...
... , , LANSING, Mich., Sept. ... Michigan is launching a television awareness campaign this holiday weekend designed ... , "Mental illness can be treated and most people ... support of their family and friends," said Sherri Solomon, Executive Director ...
... , NEW YORK, Sept. 3 Reportlinker.com announces ... catalogue. , , http://www.reportlinker.com/p0118042/Therapeutics-and-Diagnostics-for-Womens-Disorders.html ... , , Covers ... women including autoimmune diseases, women,s cancer, gynecological infections and diseases, ...
... , NEW YORK, Sept. 3 Reportlinker.com announces ... , Botanical and Plant-Derived Drugs: Global ... http://www.reportlinker.com/p0118047/Botanical-and-Plant-Derived-Drugs-Global-Markets.html , , ... the plant-derived drugs that have been commercialized to date , ...
... NEW YORK, Sept. 3 Reportlinker.com announces that a new market ... Membrane & Separation Technology News Review, 2008 , ... This report: , , , ... the global membrane and separations technology market in 2008 , ...
Cached Medicine News:Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 2Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 3Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 4Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 5Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 6Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 7Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 8Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 9Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 10Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 11Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 12Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 13Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 14Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 15Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 16Health News:Reportlinker Adds U.S. Markets for Addiction and Substance Abuse Treatment Report 17Health News:Reportlinker Adds Healthcare Information Technology Report 2Health News:Reportlinker Adds Healthcare Information Technology Report 3Health News:Reportlinker Adds Healthcare Information Technology Report 4Health News:Reportlinker Adds Healthcare Information Technology Report 5Health News:Reportlinker Adds Healthcare Information Technology Report 6Health News:Reportlinker Adds Healthcare Information Technology Report 7Health News:Reportlinker Adds Healthcare Information Technology Report 8Health News:Reportlinker Adds Healthcare Information Technology Report 9Health News:National Alliance on Mental Illness (NAMI Michigan) Launches TV Awareness Campaign 2Health News:Reportlinker Adds Therapeutics and Diagnostics for Women's Disorders Report 2Health News:Reportlinker Adds Therapeutics and Diagnostics for Women's Disorders Report 3Health News:Reportlinker Adds Therapeutics and Diagnostics for Women's Disorders Report 4Health News:Reportlinker Adds Botanical and Plant-Derived Drugs: Global Markets Report 2Health News:Reportlinker Adds Botanical and Plant-Derived Drugs: Global Markets Report 3Health News:Reportlinker Adds Botanical and Plant-Derived Drugs: Global Markets Report 4Health News:Reportlinker Adds Membrane & Separation Technology News Review, 2008 Report 2Health News:Reportlinker Adds Membrane & Separation Technology News Review, 2008 Report 3
... cleanser will not leave your hands dry, ... With persistent Antimicrobial action, CHG Skin Cleanser ... gram-negative and gram-positive bacteria, fungi, and yeasts. ... second hand wash. The solution does not ...
IV Prep Antiseptic Wipes are effective and easy to apply. They are ideal for preparation of the skin prior to a ventipuncture or injection....
Aplicare's Prep Pads offer convenience, low cost, ease of use. The medium size is appropriate for most applications. Each package is terminally sterilized, ensuring the safest possible product for th...
... Triad Plus Skin Protectant Swabsticks prepare ... dressing or bandage. When dry, they leave ... This provides a clean surface and a ... affect the adhesion of a dressing or ...
Medicine Products: