Navigation Links
Pearl Therapeutics' Bronchodilator Combination PT003 Provides Superior Inspiratory Capacity Compared to Spiriva®
Date:9/26/2011

>

In this Phase 2b study, patients with moderate-to-very severe COPD were randomized to receive one of two doses of PT003, PT001, one of two doses of PT005, Spiriva, Foradil® Aerolizer® (formoterol fumarate inhalation powder), or placebo. The two doses of PT003 (72 mcg GP/9.6 mcg FF and 36 mcg GP/9.6 mcg FF) and Spiriva provided statistically significant improvements in IC compared to placebo on day one (p<0.0001 all comparisons) and on day seven (p<0.0004 all comparisons). Both doses of PT003 provided a benefit on day one relative to Spiriva, with the higher dose showing statistical difference vs Spiriva (p<0.05). Further improvement was observed with chronic dosing, with both doses of PT003 providing a statistically significant benefit on day seven pre-dose and two hours post-dose relative to Spiriva (p<0.05).

"These results provide important early evidence of the broad clinical promise inherent in Pearl's fixed-dose bronchodilator combination, PT003 for patients suffering from debilitating effects of COPD," said Chuck Bramlage, Pearl's CEO. "These results strengthen our confidence in sustaining PT003's rapid progress towards late stage clinical development in 2012."

Pearl will also present at ERS an analysis of the efficacy of the two LAMAs studied in this trial, PT001 (36 mcg, BID) and Spiriva (18 mcg, QD). Both PT001 and Spiriva were shown to provide superior bronchodilation compared to placebo, yielding mean improvements in FEV1 (AUC 0-12) of 189 mL and 195 mL, respectively (p<0.0001 for both). The difference between these values was 6 mL, demonstrating that PT001 is statistically similar (non-inferior) to Spiriva (95% confidence interval -49; 38).

Poster Details
Date & Time: Sunday, September 25, 2011; 12:50pm – 2:40pm
Thematic Poster Session: Bronchodilators in asthma and COPD; Session 96
Title: "Fixed
'/>"/>

SOURCE Pearl Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Pearl Therapeutics Announces Positive Results for Phase 2b Dose-Ranging Study of Formoterol MDI
2. Pearl Therapeutics Advances Its Long-Acting Bronchodilator Combination Product Candidate into Four Additional Phase 2 Studies
3. Pearl Therapeutics Phase 2b Results Show a 50% Improvement in Lung Function with PT003 Compared to Spiriva® and Foradil® in Patients with COPD
4. Asante Solutions Receives FDA Clearance for Pearl™ Insulin Pump
5. Pearl Therapeutics Highlights Its Porous Particle Cosuspension Platform, Demonstrating Universal Applicability Across Multiple Drug Classes and Combination Products
6. Pearl Therapeutics to Present Complete PT003 Results from Phase 2b COPD Study in a Late-Breaker Session at the American Thoracic Society Annual Meeting
7. Asante Solutions, Inc. Receives CE Mark for Pearl™ Insulin Pump
8. Orexigen Therapeutics to Present at the JMP Securities Healthcare Conference
9. Afraxis Enters Collaboration with NIH as Part of Therapeutics for Rare and Neglected Disease Program
10. Reed V. Tuckson, M.D., Executive Vice President and Chief of Medical Affairs at UnitedHealth Group, Joins Board of Directors of Cell Therapeutics, Inc. (CTI)
11. Prime Therapeutics Launches CareCentered Contracting™ Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... -- Luminex Corporation (Nasdaq: LMNX ) today announced ... quarter of 2013 on Monday, February 3, 2014. A ... after the close of trading. (Logo: ... conference call to discuss the operating highlights and financial ... December 31, 2013 on February 3, 2014, at 5:00 ...
(Date:1/14/2014)... -- Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of ... Home Medical Equipment, Inc. ("Progressive") of Clarion, PA ... acquisition were not disclosed. Progressive is a ... range of sleep, mobility, and respiratory products to customers in ... Pittsburgh markets. Progressive was founded in 2005 by ...
(Date:1/14/2014)... PLYMOUTH, Minn. , Jan. 14, 2014   NuAire ... for research, have come to agreement with Hitachi Koki ... service the Hitachi brand of centrifuges in North ... professionals throughout the United States and ... use, product benefits and features, options and accessories, training, pricing, ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... U.S. Food and Drug Administration is warning the public ... law enforcement personnel as part of a continued international ... The criminals call the victims -- who ... or via "telepharmacies" -- and identify themselves as FDA ...
... EDDA Technology, a leading provider of advanced computer ... successful commercial installation of its IQQA®-Liver Enterprise product ... one of the top performing living donor liver ... use EDDA Technology,s IQQA®-Liver Enterprise in conjunction with ...
Cached Medicine Technology:FDA Warns Public of Continued Extortion Scam By FDA Impersonators 2FDA Warns Public of Continued Extortion Scam By FDA Impersonators 3EDDA Technology Successfully Installs IQQA®-Liver at Mayo Clinic in Arizona 2
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... say that once the virus takes hold in any country ... // Officials admitted that they are facing an uphill battle ... easily from person to person, triggering a pandemic. ,The ... poultry, one of the most crowded places on earth and, ...
... Clark Gable's son has been exposed as a drug addict ... ,According to contactmusic.com, the daughter Kaylee feels that her grandfather ... his son, actor John Clark Gable, now. , ,She ... I know if my grandfather were alive today it would ...
... to new things and accepts them, although medical transcription is not ... records in papers and are not well stocked in most cases. ... records., ,In contrast, in the US, medical case files are ... industry in the US is well established. It is more than ...
... Fifteenth Annual Meeting and Clinical Congress to be held ... discuss important benefits //of vitamin D and the problems ... ,Vitamin D has been in the new recently and ... attributed to it. Recent studies have highlighted its deficiency ...
... researchers say that the distinctive features of the heart ... of a genetic quirk that is linked to a ... ,Steve Ommen, M.D., director of Mayo’s HCM Clinic ... said that the currently available test was only able ...
... Brachytherapy, which is touted as the best and latest ... Sydney's Mater Hospital Radiotherpahy Department.// ,It is ... set to improve results with fewer side effects. ... the southern hemisphere, bringing together image-enhancing technology that builds ...
Cached Medicine News:Health News:Rising in career top charts is Medical transcription 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: