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Pearl Therapeutics' Bronchodilator Combination PT003 Provides Superior Inspiratory Capacity Compared to Spiriva®
Date:9/26/2011

REDWOOD CITY, Calif., Sept. 26, 2011 /PRNewswire/ -- Pearl Therapeutics Inc. presented additional positive results from its  Phase 2b study (NCT01085045) demonstrating that the dual bronchodilator combination product, PT003 (GFF MDI) provides superior inspiratory capacity (IC) compared to Spiriva® HandiHaler® (tiotropium bromide inhalation powder). IC is a lung function measurement that has been shown to be predictive of improvement in exercise performance in patients with COPD. PT003 is a proprietary fixed-dose combination of glycopyrrolate (GP), a long-acting muscarinic antagonist (LAMA) and formoterol fumarate (FF), a long-acting beta-2 agonist (LABA) delivered via a pressurized hydrofluoroalkane metered dose inhaler (HFA MDI). In a separate analysis, the Company also confirmed the comparability of their monotherapy, PT001 (GP MDI) to Spiriva. Both PT003 and PT001 products are based on Pearl's novel cosuspension formulation platform for metered dose inhalers. These data are being presented at the 2011 European Respiratory Society (ERS) annual meeting, which is being held in Amsterdam.

"It has recently been shown that the progressive reduction of resting IC is associated with the development of an increasingly shallow, rapid breathing pattern and worsening shortness of breath during exercise," explained Colin Reisner, Pearl's chief medical officer and executive vice president of clinical development. "Improvement in IC correlates well with improvement in dyspnea at rest and with exercise, as well as overall exercise endurance. PT003 provided substantial improvement in IC relative to Spiriva after the initial dose, with further improvements following chronic dosing. These data suggest that PT003 may provide significant improvements in symptomatic benefits and exercise performance and supports further evaluation." '/>"/>

SOURCE Pearl Therapeutics Inc.
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