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Patients Who Know Their Gene Test Results are More Likely to Regularly Take and Remain on Statins, Study at ACC Shows
Date:3/26/2012

its of pharmacogenetic testing."

Study Details
The study examined medication adherence of 1,294 patients that were newly prescribed statins.  A laboratory-developed gene test to measure KIF6 carrier status was provided to 647 patients while 647 patients in the control group did not receive a genetic test.  The two groups were matched for age, gender, prescription distribution channel, and the number of chronic medications used.  After controlling for other patient characteristics known to affect adherence (such as co-morbidities and socioeconomic status), tested patients who were informed of their test result had significantly higher overall adherence to their statin treatment as measured by the proportion of days with medication on hand over a six-month period, the study's primary end point (77 percent of days covered versus 68 percent). 
Furthermore, tested patients were almost two times more likely (99 percent) to be categorized as adherent as measured by patients who had statin medication on hand 80 percent or more of the time. They were also 83 percent more likely to be persistent, meaning they stayed on their statin therapy for the full six months.  AKROBATS is registered on www.clinicaltrials.gov (NCT01068834).

"We focused on statins in this study because of the tens of millions of patients prescribed these medications in the US every year, the drug spend, the known low degree of adherence and persistence to them, and the modest impact of most adherence interventions to date," said Dr. Eric Stanek, MRI vice president, and senior author on the study.  "Given the well-established relationship between increasing statin adherence and reduced cardiovascular events and overall costs, as well as improved workplace productivity, it's exciting to begin thinking about genetic testing or other personalized medicine approaches as useful new
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SOURCE Medco Health Solutions, Inc.
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