Navigation Links
Patient's Own Infection-Fighting T Cells Put Late-Stage Melanoma Into Long-Term Remission - Without Chemotherapy or Radiation
Date:6/18/2008

Case is first to show safety and effectiveness of using cloned cells alone

to kill tumors

SEATTLE, June 18 /PRNewswire/ -- Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.

Yee and colleagues removed CD4+ T cells, a type of white blood cell, from a 52-year-old man whose Stage 4 melanoma had spread to a groin lymph node and to a lung. T cells specific to targeting the melanoma were then expanded vastly in the laboratory using modifications to existing methods. The lab-grown cells were then infused into the patient with no additional pre- or post-conditioning therapies, such as growth-factor or cytokine treatment. Two months later, PET and CT scans revealed no tumors. The patient remained disease free two years later, when he was last checked.

"We were surprised by the anti-tumor effect of these CD4 T cells and its duration of response," Yee said. "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."

Yee cautioned that these results, presented in the journal's "Brief Report" section, represent only one patient with a specific type of immune system whose tumor cells expressed a specific antigen. More studies are needed to confirm the effectiveness of the experimental T cell therapy. If proven successful in more patients, Yee predicted this therapy could be used for the 25 percent of all late-stage melanoma patients who have the same immune-system type and tumor antigen.

Using a patient's own immune system to combat cancer, called immunotherapy, is a growing area of research that aims to develop
'/>"/>

SOURCE Fred Hutchinson Cancer Research Center
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
3. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Sixty-One Percent of Newly Diagnosed Parkinsons Disease Patients Do Not Receive Any Drug Treatment in the First Year of Diagnosis
7. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
8. Many Heart Attack Patients Dont Get Best Emergency Treatment
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. Phase 2a Multi-Dose Study Initiated by MedImmune in Patients With Asthma to Further Expand Anti-Interleukin-9 Program
11. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 23, 2014   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" ... its Scientific Advisory Board.  The new members are ... PhD. Dr. Acker is a Senior Development ...
(Date:9/22/2014)... Spain , September 23, 2014 ... to meet health authorities, increasing rigor for trial master ... life sciences industry,s largest TMF survey to date reveals ... that plan to provide auditors with remote access to ... of TMF owners surveyed in the Veeva ...
(Date:9/22/2014)... The western European automated endoscope reprocessor ... a replacement market with fewer new installations due ... partnerships are redefining competitive landscape in western ... details about revenue forecasts, unit shipments, market share ... country. The changing landscape makes it important to ...
Breaking Medicine Technology:BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 2Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 3Remote eTMF Access to Double in 2015, Reveals Industry-wide Survey 4Automated Endoscope Reprocessor Market Trends in Western Europe 2Automated Endoscope Reprocessor Market Trends in Western Europe 3
... 6, 2011 The American Animal Hospital Association ... ) are collaborating on a new series for online ... real-life examples, the "Solve It! Series" combines engaging content ... element of mystery. Designed by a panel of experts, ...
... 6, 2011 ContinuumRx and Mississippi Baptist Health Systems ... new home infusion pharmacy that will serve ... model designed to improve patient outcomes with a more ... partnership will not only improve our core operations and ...
Cached Medicine Technology:American Animal Hospital Association and Heska Corporation Announce New Online Continuing Education Series 2ContinuumRx Forms Healthcare Joint Venture with Mississippi Baptist Health Systems 2
(Date:9/23/2014)... Recently, Best Cheap Hosting USA, a popular review ... best VPS hosting suppliers in the current market. Among ... hosting is a very popular. The account owner is ... others’ websites under his name, brand or company. , ... primary hosting plans (reseller hosting and low cost shared ...
(Date:9/23/2014)... many believe that guardian angels watch over to keep ... finds that those who believe are actually less inclined ... was published today in the open access journal ... Susan MacGregor, and Alalia Spektor surveyed 198 individuals and ... 68% said that this belief affects how they take ...
(Date:9/23/2014)... September 23, 2014 Wohl Associates ... and packaging equipment, has recently taken delivery of used ... These include mixers, sheeters, and equipment for producing gnocchi ... pound Toresani unit and a La Parmigiana mixer/extruder. With ... features a mixing tank that is 17” wide, 28” ...
(Date:9/23/2014)... Humans do not do nearly as good a ... says leading waste water management expert Neil Grigg, PhD. In ... 100% of all water used by humans would be returned ... removed. Solid waste removed from the waste water would also ... Total Water Management (TWM) concept on the Sharon Kleyne Hour ...
(Date:9/23/2014)... 23, 2014 On September 9th, 2014, the ... most technically advanced horticultural LED grow light that they have ... XL750 and XL1000 , releasing a light ... experienced horticulturalist, because it has what the whole community has ... LED's grower-tested 12 band spectrum (also known as "the perfect ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA: Bluehost And JustHost Are Ranked As The Best VPS Hosting Suppliers 2Health News:Used Industrial Pasta Machinery Now Available at Wohl Associates 2Health News:Leading Water Treatment Expert Calls for 100% Waste Water Recycling 2Health News:Leading Water Treatment Expert Calls for 100% Waste Water Recycling 3Health News:Kind LED K5 Series XL1000 Grow Lights Sell Out in Only 2 Days 2
... August 16, 2011 Seattle Children,s Research Institute ... million grant from the Bill & Melinda Gates ... respiratory support device, called Seattle Children,s Positive Airway ... affordable and simple Bubble Continuous Positive Airway Pressure ...
... Italy, August 16, 2011 Facial expressions convey strong ... interpret these cues is crucial in social interaction. This ... and neurological disorders, such as social anxiety or Korsakoff,s ... stress disorder (PTSD) is also characterized by changes in ...
... 16 (HealthDay News) -- Many women in the United States ... due to dangerous ingredients, a new study indicates. Pai ... which are banned in the United States because they increase ... U.S. Food and Drug Administration announced a recall of Pai ...
... exercise routine means being able to overcome the obstacles ... the confidence that you can do it, researchers report. ... abilities increase this "situation-specific self-confidence," a quality the researchers ... self-efficacy to every single health behavior you can think ...
... 15 (HealthDay News) -- You might want to take a ... researchers report that alcohol hinders the restorative functions of sleep. ... students, appear online and in the November print issue of ... Booze,s effect on sleep appears linked to a disruption ...
... , MONDAY, Aug. 15 (HealthDay News) -- ,Just 15 ... death by 14 percent and increase your life expectancy by three ... to do at least 150 minutes, or a total of 1.5 ... finds that doing even half that -- 15 minutes daily is ...
Cached Medicine News:Health News:Seattle Children's lands major funding with hopes of saving thousands of infant lives 2Health News:Seattle Children's lands major funding with hopes of saving thousands of infant lives 3Health News:Reduced recognition of fear and sadness in post-traumatic stress disorder 2Health News:U.S. Women Using Dangerous Weight-Loss Pill 2 Years After Recall 2Health News:Want to keep your exercise resolutions? New research offers pointers 2Health News:Want to keep your exercise resolutions? New research offers pointers 3Health News:More Evidence That Alcohol Hinders Good Sleep 2Health News:A Little Exercise Goes a Long Way to Cut Disease, Death Risk 2
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Smooth, rounded working end manipulates organs less traumatically. Used as a general manipulative instrument....
This probe coagulates bleeders while suction channel with trumpet valve simultaneously evacuates smoke....
Medicine Products: