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Patient Enrollment Complete in First Trial to Compare Physiologic Guidance vs. Angiographic Guidance of Stent Deployment in Patients with Multivessel Disease
Date:10/22/2007

nctional class at one year, number of anti-anginal drugs after one year, overall MACE rate at one month post-procedure and at six months, two, three and five years.

"With drug-eluting stents (DES) and lower restenosis rates, interventional cardiologists are performing PCI more often in patients with increasingly complex CAD, including multivessel disease," said Dr. De Bruyne. "Furthermore, some physicians are stenting all intermediate lesions with DES regardless of the physiologic significance of those lesions. DES are expensive and have been associated with potential late complications. Therefore, the objective of FAME is to help us identify an approach to PCI that will improve overall clinical outcomes and reduce healthcare expenditure."

In addition to Dr. De Bruyne, the FAME study's investigators are represented by Nico H. J. Pijls, M.D., Ph.D.; Pim Tonino, M.D.; Uwe Siebert, M.D., M.Sc., M.P.H., Sc.D.; and William Fearon, M.D. A paper outlining the rationale and design of the trial is published in the October issue of American Heart Journal (American Heart Journal Vol.154, No. 4, pp.632-636). For more information about the FAME study, visit http://clinicaltrials.gov/ct/gui/show/NCT00267774?order=17 .

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