Navigation Links
Particle Sciences Develops Wax Nanoparticles that Enhance Immune Response to Antigens
Date:12/22/2010

BETHLEHEM, Pa., Dec. 22, 2010 /PRNewswire/ -- Particle Sciences Inc. (PSI), a leading pharmaceutical CRO has formulated a series of wax nanoparticles that, when coupled with an antigen, enhanced its immunogenicity, increasing both systemic and the mucosal immune response.  The work is described in Vaccine, 2010 Dec. 8 in an article titled "Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen."

In the paper, it is shown that by charge coupling the antigen with the wax nanoparticles, intradermal vaccination resulted in high levels of specific IgG response equal or greater than that of traditional adjuvants.  Additionally, intranasal vaccination with antigen coupled wax nanoparticles induced a significant mucosal response.  By themselves the wax nanoparticles are non-inflammatory.  

The experimental work was performed at the Division of Clinical Sciences, St George's University, London and lead by Dr. Mauricio Arias.  

According to Dr. Andrew Loxley, Particle Sciences Director of New Technologies, "While these are preliminary experiments, the data is very encouraging and we are hopeful this approach can be exploited in the creation of more effective and affordable vaccines."  Dr. Loxley also notes, "The wax nanoparticles are stable to storage and easily and affordably produced."

Particle Sciences is an integrated provider of drug development services. Particle Sciences focuses on emulsions, gels, nano and micro-particulates and drug/device combination products with a focus on API's with difficult solubility profiles. Through a full range of formulation, analytic, and manufacturing services, Particle Sciences provides pharmaceutical companies with a complete and seamless development solution that minimizes the time and risk between discovery and the clinic. The company was founded in 1991 and is headquartered in Bethlehem, Pennsylvania. Visit www.particlesciences.com, email info@particlesciences.com or contact us at (610) 861-4701 for information.

Contact: Maureen Cochran

mcochran@particlesciences.com




'/>"/>
SOURCE Particle Sciences Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Targeted Nanoparticles Offer Promise in the Battle Against Cancer
2. IBA and Elekta Initiate Global Particle Therapy Program at ASTRO
3. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
4. Celator(R) Pharmaceuticals Successfully Uses Nanoparticles to Administer Hydrophobic Drug Combinations
5. Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds
6. Particle Sciences Expands Its Combination Product Capabilities
7. Novavax Reports Positive Preclinical Results for a Novel, Broadly Cross-Protective H5N1 Pandemic Influenza Virus-like Particle (VLP) Vaccine Candidate
8. Particle Sciences and IES Engineers Cooperate on High Potency Compound Handling Capabilities
9. MicroConstants Now Offers Nanoparticle Formulation Services
10. ChemImages Raman Chemical Imaging Used for Ingredient-Specific Particle Sizing for Inhalation Product Development
11. Varian Medical Systems Introduces ProBeam(TM) Proton Therapy Platform at Particle Therapy Co-operative Group (PT COG) 2010 Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... , June 6, 2017  Diplomat Specialty Infusion Group, a brand ... environment to its Iowa location. ... now features an ISO 7 cleanroom—the standard needed to ... with a low level of pollutants. ... nutrition consumers and better serve our Iowa ...
(Date:6/1/2017)... Nutriceutical Holdings (NH), parent company of Physician ... KD Pharma Group have decided to join forces through ... Group. KD Pharma Group will become the largest shareholder ... entire company. "We believe we have found ... growing the NH companies by providing us with supply ...
Breaking Medicine Technology:
(Date:6/26/2017)... ... June 26, 2017 , ... ... and consumers are seeing lots of red these days. According to recent estimates, ... that result from medical coding errors(1). Some studies point to Electronic Health Records ...
(Date:6/26/2017)... ... June 26, 2017 , ... New patients with missing ... Cotey, with or without a referral. Dr. Cotey is a trusted dentist who has ... tooth replacement option. , Patients with missing teeth in Fitchburg, WI, are encouraged to ...
(Date:6/25/2017)... ... June 24, 2017 , ... Create a feel-good lyric music video in Final Cut ... sound in the timeline and write in the lyrics to any song. ProLyric flies in ... Each line of the text can be added modularly for optimal control. ProLyric makes editing ...
(Date:6/25/2017)... ... ... An increase in wetter weather in the Northern California area naturally means ... humdinger of an allergy season. A relief from drought conditions is most welcome, but ... weed pollen. , “Our patients have been reporting the typical allergy season symptoms, ...
(Date:6/25/2017)... ... ... a heatwave currently bearing down on Northern California pushing temperatures to the maximum, many people ... easy with laser hair removal. , The process of summer waxing and constantly shaving ... you want to do is get out, dive in and cool off. There is a ...
Breaking Medicine News(10 mins):