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Parkinson's Disease: World Drug Market 2013-2023
Date:3/4/2013

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7.3 How Will We Know Disease Modification if We See It? Progress in Biomarkers, Imaging and Disease Models

7.3.1 The $30m Search for PD Biomarkers

7.3.2 When Will We Have Robust PD Biomarkers?

7.3.3 Players in the PD Biomarkers Field

7.3.4 SPECT, PET and MRI: Shining a Light on PD

7.3.5 Disease Process, not Disease Endstage: New Animal Models for Disease Modification

7.4 Candidates for Disease Modification: Pipeline Overview

7.5 Coenzyme Q10 (National Institute of Neurological Disorders and Stroke [NINDS])

7.5.1 A Nutritional Supplement with Limited Commercial Scope

7.5.2 Nearly Two Decades of Investigation

7.5.3 Dietary Supplements as Disease Modifiers

7.6 Repurposing Existing Drugs for PD

7.7 Exenatide (University College London)

7.7.1 Rationale for Repurposing Exenatide

7.8 Isradipine (The Parkinson Study Group)

7.8.1 Blocking Brain Calcium Channels

7.9 Other Possible Small-Molecule Disease-Modifying Agents

7.10 Cogane (Phytopharm)

7.10.1 Cogane's Possible Disease-Modification Mechanism

7.10.2 One of the Leading Small Molecules in the Disease Modification Hunt

7.11 AZD3241 (AstraZeneca): First Myeloperoxidase Inhibitor in PD Trials

7.12 AT2101/AT3375 (Amicus Therapeutics): Innovative 'Pharmacological Chaperone'

7.13 VAR 10300 (Varinel): Virtual Company's Possible PD Candidate

7.13.1 Multiple Mechanisms of Action

7.14 NP001 (Neuraltus)

7.15 XP23829 (XenoPort): A Promising Prodrug

7.16 GDNF and Other Growth Factors: A Neglected Possibility?

7.17 MANF (Amarantus BioSciences): A Future Biological Blockbuster?

7.18 Peptide Drugs

7.19 GM6 (Genervon Biopharmaceuticals)

7.19.1 Impressive Animal Model Results

7.20 NNZ-2591 (Neuren Pharmaceuticals)

7.21 Davunetide (Allon Therapeutics)

7.22 Gene Therapies

7.23 ProSavin (Oxford BioM
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