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Parkinson's Disease: World Drug Market 2013-2023
Date:3/4/2013

o Market?6.16.1 The New Generation of Glutamatergic Drugs6.16.2 AFQ056 vs. Dipraglurant6.16.3 AQW051: Novartis Also Targeting Nicotinic Receptors6.16.4 Nicotinic Receptor Targeting6.17 Dipraglurant-IR (Addex Therapeutics): Competing for the mGluR5 Market6.17.1 Allosteric Modulators: An Emerging New Approach6.17.2 Can Dipraglurant Become a New PD Blockbuster?6.17.3 ADX88178 (Addex Therapeutics)6.17.4 Domain Therapeutics: Targeting the Same Therapeutic Approach6.18 Fipamezole (Santhera Pharmaceuticals): Another Challenger in the A2a Antagonist Space6.19 CVT-301 (Civitas Therapeutics): Levodopa for the Deep Lung6.20 DM-1992 (Depomed): Gastric Retention Levodopa6.21 Accordion Pill Carbidopa/Levodopa (Intec Pharma): Another Option to Reduce Levodopa Dosing Needs6.22 Oxybutynin and Clonidine Oral Solution (Orient Pharma): Treatment for Sialorrhoea6.22 Sialorrhoea: A Socially Difficult Symptom of PD6.23 NH004 (NeuroHealing) 6.24 VR040 (Vectura Group)6.25 XP21279 (XenoPort)6.26 The Phase 1 and Preclinical Pipeline: Overview6.26.1 ND0611 (Neuroderm) 6.27 Neu-120 (Neurim Pharmaceuticals)6.28 Ordopidine (Neurosearch)6.29 ProNeura Continuous Release Dopamine Agonist (Titan Pharmaceuticals)6.30 V81444 (Vernalis): Regained Rights from Biogen Idec6.31 AVE8112 (Sanofi/MJFF)6.32 SKL-PD (SK Biosciences)

7. The Next Frontier in PD Treatment: Disease-Modifying Treatments R&D Pipeline

7.1 Disease Modification and Neuroprotection: Basic Concepts

7.1.1 Why Do Cells Die in PD and What Would Stop Them?

7.2 Azilect: the Leading Candidate Neuroprotectant Among Existing Approved Drugs

7.2.1 Azilect's Presumed Neuroprotective Mechanisms of Action

7.2.2 How can Neuroprotective Effects be Measured?

7.2.3 Early Interventions and Delayed Starts

7.2.4 'This is Close, But It's Not Good Enough': The ADAGIO Trial Verdict

7.2.5 Where Does the Failure of the Azilect Trial Leave the Disease Modification Concept
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