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Parion Sciences Announces Phase I Clinical Results for Novel Dry Mouth Treatment
Date:4/7/2008

al of this drug candidate to bring relief to a quality of life issue faced daily by these patients," said M. Ross Johnson, Parion Chief Executive Officer. "Based on these results, we plan to proceed with a Phase I/IIA study designed to test the efficacy of higher concentrations of P-552-02 delivered in a spray formulation and dosing at different intervals, and to pursue other potential indications."

Epithelial sodium channel blockers, such as P-552-02, are unique therapeutic agents that stimulate and maintain hydration on the body's mucosal surfaces, including those on the lung, mouth, nose, eye and gastrointestinal tract. Restoring the hydration of mucosal surfaces in the mouth addresses the fundamental problem that causes the extreme dryness of Sjogren's syndrome.

Sjogren's syndrome is a chronic disorder that occurs when a person's normally protective immune system attacks and destroys moisture-producing glands, including the salivary and tear glands. There are currently no specific topical pharmaceutical medications to alleviate the symptoms of dry mouth associated with Sjogren's syndrome, which can cause difficulty with chewing and swallowing, decreased sense of taste, hoarseness, coughing and an increase in dental cavities.

About Parion Sciences

Based in Durham, NC, Parion Sciences is a privately-held, development- stage pharmaceutical company that is leveraging its proprietary small molecule chemistry and epithelial biology expertise to discover and develop an innovative pipeline of therapies for diseases resulting from the failure of the body's mucosal defenses, including Sjogren's syndrome, dry eye, certain pulmonary diseases, and diverticulitis and other gastrointestinal diseases, as well as biodefense applications. Parion's lead product candidate, P-552-02, has completed a Phase I clinical trial in Sjogren's syndrome and a Phase II clinical trial in cystic fibrosis. In August 2007, Parion announced a collaboration with Gilead Sc
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SOURCE Parion Sciences, Inc.
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