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Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
Date:8/19/2007

WOODCLIFF LAKE, N.J., Aug. 3 /PRNewswire-FirstCall/ -- Par Pharmaceutical Companies, Inc. (NYSE: PRX) today announced it had begun shipping metoprolol succinate extended release 50 mg tablets. As previously announced, in November 2006 Par entered into a supply and distribution agreement with AstraZeneca in the U.S. to distribute metoprolol succinate extended release tablets, which is substitutable for AstraZeneca's TOPROL-XL(R) extended release tablets. Par began shipping 25 mg tablets of generic Toprol-XL at that time.

TOPROL-XL is a beta-1-selective (cardioselective) adrenoceptor-blocking agent, for oral administration, available as extended release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration.

Annual U.S. sales of TOPROL-XL in the 50 mg tablet are approximately $640 million, according to IMS Health.

Important information about metoprolol succinate extended release tablets

Metoprolol succinate extended release is indicated for the treatment of hypertension, alone or in combination with other antihypertensives; the long- term treatment of angina pectoris; and the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digitalis.

Metoprolol succinate extended release is contraindicated in severe bradycardia, heart block of greater than first degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless permanent pacemaker is in place), and in patients who are hypersensitive to any component of this product.


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SOURCE Par Pharmaceutical Companies, Inc.

Copyright©2007 PR Newswire.

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