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Paper Published in American Journal of Cardiology Demonstrates Favorable Vascular Healing Following MiStent SES Implantation
Date:11/21/2013

DURHAM, N.C., Nov. 21, 2013 /PRNewswire/ -- Micell Technologies, Inc. today announced that The American Journal of Cardiology® published results of a comprehensive analysis of optical coherence tomography (OCT) following MiStent SES implantation. Evaluations of vascular healing taken at multiple time points demonstrated excellent vessel healing with a low rate of neoatherosclerosis. The MiStent Sirolimus Eluting Absorbable Polymer Coronary Stent System (MiStent SES®) is a thin-strut drug-eluting stent that was developed to optimize vessel healing, and which is distinguished by a rapidly absorbable coating that controls the rate of drug release.

Data presented in this paper were additional findings from Micell's DESSOLVE I trial of MiStent SES, in which 30 patients with coronary artery disease were enrolled. The study design allowed for the assessment of vascular responses at four, six, eight and 18 months post-implantation to enhance the understanding of the vascular healing process over time. An evaluation of the healing process spectrum following DES implantation through serial assessments at various time points of neointimal hyperplasia (NIH), coverage, apposition, and tissue characteristics yielded these key results:

  • Lower rates of neoatherosclerosis following MiStent SES implantation as compared to previously reported results with other drug-eluting stents.
  • High rates of stent coverage in early follow-up, with further improvement at 18 months' follow-up.
  • Stent strut malapposition that was low at all time points, and an established trend toward additional reduction at 18 months.
  • NIH thickness, area and volume that remained static from eight to 18 months without evidence of late restenosis.

Marco Costa, M.D., Director, Center for Research
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SOURCE Micell Technologies, Inc.
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