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Panel of Osteoarthritis Experts Develops Optimal Profile of Exogenous Hyaluronic Acid
Date:11/18/2009

NEWTOWN SQUARE, Pa., Nov. 18 /PRNewswire/ -- A panel of osteoarthritis (OA) key opinion leaders has developed a consensus of the optimal exogenous hyaluronic acid (HA) treatment. This consensus was achieved by utilizing what the experts referred to as BioRestorative(TM) Profiling. This profiling examines HAs on the basis of their mimicking the body's natural HA. "BioRestorative(TM)" describes the features of the ideal HA product, based on the treatment goals of symptom relief, improvement in function, and improved quality of life. In a comparison of available HA products, EUFLEXXA® (1% sodium hyaluronate) best matched the BioRestorative profile. Results of the panel's discussion were published in an independent educational publication authored by members of The Institute for Clinical Care, accessible at www.clincare.org. The report was sponsored by Ferring Pharmaceuticals Inc., the maker of EUFLEXXA®, and published by Dardine & Associates, LLC.

Features of the Ideal HA Product

The panel hypothesized that the exogenous HA product likely to yield the best results in OA treatment is one that most closely resembles endogenous human HA in all ways, including size, structure and molecular weight. The ideal HA would have high viscosity and high molecular weight. When injected, it would supplement the synovial fluid inside the knee and lubricate and protect the joint. The product would also be as pure as possible, containing no contaminants or animal proteins. A low protein concentration lowers the risk of inflammatory reactions and pseudosepsis.

"The term 'BioRestorative' suggests that an ideal HA has a restorative effect on naturally occurring synovial fluid in the joint," said panel leader Dr. Jeffrey E. Rosen, Chairman, Department of Orthopaedics and Physical Medicine & Rehabilitation at New York Hospital Queens. "Of the currently marketed HA products, non-avian EUFLEXXA® most closely
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SOURCE The Institute for Clinical Care
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