Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH ...(Clinicaltrials of PAN-622 will be initia...),Health

Date:9/3/2008

Clinical trials of PAN-622 will be initiated in early 2009, with an initial indication for the treatment of liver cancer. In addition, the presence of HAAH protein in serum has been demonstrated to be highly sensitive and specific for cancer in hundreds of patients with a range of cancer types, and Panacea has developed serum diagnostic tests measuring HAAH for prostate lung, breast and colon cancer.

PAN-622 and other antibodies covered under U.S. Patent Number 7,413,737 were developed in collaboration with MIT using a proprietary yeast display technology. More detailed information is included in Yeung YA, Finney AH, Koyrakh IA, Lebowitz MS, Chanbari HA, Wands JR, Wittrup KD. Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase. Hum Antibodies, 16(3-4):163-176, 2007.

"We are excited about receiving notice of the issuance of the patent covering antibodies against HAAH, and particularly PAN-622, our all-human sequence monoclonal antibody against HAAH," noted Hossein Ghanbari, Ph.D., Chairman, CEO and CSO at Panacea Pharmaceuticals. "We are quickly advancing PAN-622 toward clinical trials and we are confident that this monoclonal antibody will prove to have tremendous potential as a cancer therapeutic agent."

"HAAH is an excellent target for monoclonal antibody cancer therapeutics, and we have developed several high affinity antibodies against HAAH with good promise as cancer therapeutics," commented K. Dane Wittrup, Ph.D., Carbon P. Dubbs Professor of Chemical Engineering & Bioengineering at the Massachusetts Institute of Technology. "PAN-622 as an all-human sequence monoclonal antibody is particularly exciting, and its efficacy in preclinical mouse models of cancer is quite encouraging."

In addition to PAN-622, Panacea is developing an antibody-toxin conjugate utilizing PAN-622. Panacea has demonstrated that anti-HAAH antibodies are internalized upon binding to the cell surface of cance
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SOURCE Panacea Pharmaceuticals, Inc. Copyright©2008 PR Newswire. All rights reserved

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