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Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting
Date:5/6/2009

e most common cause of retinal reattachment surgery failure still occurring in about 5-12% of cases. Although advances in the surgical management of PVR have improved the ability of surgeons to ultimately reattach the retina, the visual prognosis remains poor, with only 11-25% of patients achieving a visual acuity of 20/100. Presumably this permanent decrease in visual acuity is due, in part, to the loss of photoreceptors since apoptosis is a clear consequence of detachment and can continue at low levels even after the retina is reattached. While there have been numerous attempts to reduce the incidence of PVR, to date no effective pharmacological treatment has been found.

About the PI3K/Akt/mTOR Pathway and Palomid 529

The PI3K/Akt/mTOR pathway has been implicated in a wide variety of biological responses and is considered a major therapeutic target in several different diseases. Activation and subsequent deregulation of this signaling pathway, via direct or indirect mutagenic events, is common in many types of human diseases. Thus, agents capable of inhibiting the pathway are attractive targets for therapeutic intervention. Central to the signalling pathway are two distinct protein complexes, one of which, TORC1, regulates cell growth by acting on the signal transduction protein S6K, while the other, TORC2, regulates cell survival through Akt. These complexes define the rapamycin-sensitive and insensitive branches of the PI3K/Akt/mTOR pathway. Inhibitors of TORC2 may have beneficial effects without toxicity to normal tissues since loss of TORC2 in genetically altered mice does not appear to affect normal tissue. TORC1 antagonists such as rapamycin (Sirolimus) have shown activity in both animal models of ocular disease and in human clinical trials. The inhibition of both TORC1 and TORC2 should result in more complete inhibition of aberrant PI3K/Akt/mTOR signaling and are therefore of active interest for pharmaceutical
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SOURCE Paloma Pharmaceuticals, Inc.
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