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Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting
Date:5/6/2009

"Retinal detachment can occur following trauma or as part of certain diseases of the eye resulting in blindness in the affected area. In some cases, blindness or other visual deficits may be permanent, and related to the death of photoreceptor cells, the cells responsible for capturing light in the retina. We have presented data at ARVO demonstrating that a single intraocular injection of Palomid 529, a drug originally designed as an anti-angiogenic agent, can significantly reduce this death in an animal model of retinal detachment. In addition, we show that Palomid 529 also reduces the activation of glial cells and subsequently slows the formation of subretinal scar tissue, a condition that can prevent the regeneration of photoreceptors following successful retinal reattachment surgery. Taken together these data suggest that Palomid 529 may be neuroprotective to photoreceptors and reduce the incidence of subretinal fibrosis without obvious side effects to the retina," says Dr. Lewis, study investigator.

About Retinal Detachment

Retinal detachments can occur for a variety of reasons and, in general, can be repaired by retinal surgeons. Two potentially devastating complications of retinal detachment, however, are proliferative vitreoretinopathy (PVR) and subretinal fibrosis (scarring). When the retina becomes separated from the retinal pigment epithelium (RPE) because a tear or hole occurs in the retina, many cell types undergo proliferation and consequently have the potential to form retinal scars. When such cell types are present in the space between the retina and the RPE, subretinal fibrosis is the result and can prevent the recovery of photoreceptor cells even though the retina is reattached. When such cells grow on the vitreal surface of the retina, they can form contractile scar tissue leading to re-detachment of the retina. Together, these conditions are termed proliferative vitreoretinopathy (PVR). PVR remains th
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SOURCE Paloma Pharmaceuticals, Inc.
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