Navigation Links
Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer
Date:6/2/2009

ed gastrointestinal and other severe toxicities.

About OPAXIO(TM)

OPAXIO(TM) (paclitaxel poliglumex, CT-2103), which was formerly known as XYOTAX(TM), is an investigational, biologically enhanced, chemotherapeutic that links paclitaxel, the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer, which results in a new chemical entity. When bound to the polymer, the chemotherapy is rendered inactive, potentially sparing normal tissue's exposure to high levels of unbound, active chemotherapy and its associated toxicities. Blood vessels in tumor tissue, unlike blood vessels in normal tissue, are porous to molecules like polyglutamate. Based on preclinical studies, it appears that OPAXIO is preferentially distributed to tumors due to their leaky blood vessels and trapped in the tumor bed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may be influenced by estrogen, which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer compared to standard therapies.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit www.CellTherapeutics.com.

Sign up for email alerts and get RSS feeds at our Web site, http://www.celltherapeutics.com/investors_news.htm

This
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer
2. Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimers Disease
3. Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated
4. Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
5. Ceremeds OSTENE(R) Stops Bone Bleeding Without Added Risk of Surgical Infection, New Study Finds
6. Zetia Does Not Reduce Carotid Plaque Size When Added to Zocor
7. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
8. Muscadine Grape Skin Dietary Supplement Protects against Cancer Therapy Radiation Side Effects
9. Winning the War on Cancer: The Critical Role of Radiation Oncology
10. Breast MRI Scan Could Determine Need for Radiation Therapy
11. High Intensity Focused Ultrasound for Locally Recurrent Prostate Cancer Following External Beam Radiation Therapy Investigated in Phase III Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 23, 2014 Rising health ... and increasing number of foreign and domestic players in ... India   The ... most high growth potential markets worldwide due to multiple ... among the youth, changing food consumption patterns, increasing diabetic ...
(Date:9/23/2014)... 23, 2014  Vesselon, Inc. today announced the appointment ... effective September 15, 2014. Dr. Raths, appointment follows Vesselon,s ... agent to market a private preferred Series A round ... treatment. "Jurgen,s deep experience across multiple functional ... asset to Vesselon as we develop our device that ...
(Date:9/23/2014)... 23, 2014   COTA, Inc. today announced ... million Series A funding round led by Horizon Healthcare ... the first big data platform designed by practicing oncologists ... for cancer care in support of healthcare,s new value-based ... expand development of the COTA platform, hire biostatisticians, outcome ...
Breaking Medicine Technology:India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 2Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 3COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 2COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 3COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 4
...  ZHUHAI, China, Oct. 24, 2011 ... a leading global manufacturer of electronic medical devices ... worldwide technology licensing agreement and the launch of ...  new generation of modular patient monitors. The agreement ...
... Mont., Oct. 24, 2011 Bacterin International ... leader in the development of revolutionary bone graft material and ... at the Singular Research,s Sixth Annual ,Best of the Uncovereds, ... Boulevard Hotel in Los Angeles, California. Bacterin,s chairman ...
Cached Medicine Technology:Guangdong Biolight Meditech Co., Ltd. Announces the Launch of Its Modular Patient Monitors with Masimo rainbow SET Pulse CO-Oximetry Technology 2Guangdong Biolight Meditech Co., Ltd. Announces the Launch of Its Modular Patient Monitors with Masimo rainbow SET Pulse CO-Oximetry Technology 3Guangdong Biolight Meditech Co., Ltd. Announces the Launch of Its Modular Patient Monitors with Masimo rainbow SET Pulse CO-Oximetry Technology 4Guangdong Biolight Meditech Co., Ltd. Announces the Launch of Its Modular Patient Monitors with Masimo rainbow SET Pulse CO-Oximetry Technology 5Guangdong Biolight Meditech Co., Ltd. Announces the Launch of Its Modular Patient Monitors with Masimo rainbow SET Pulse CO-Oximetry Technology 6Bacterin to Present at Sixth Annual Singular Research 'Best of the Uncovereds' Conference on October 26, 2011 2
(Date:9/23/2014)... Sinica, the preeminent academic institution in the Republic ... agreement to develop a unique educational and scientific ... to translate innovative technologies and commercially relevant discoveries ... Sept.12 in Taipei by Harris Lewin, vice chancellor ... Wong of Academia Sinica. The program will be ...
(Date:9/23/2014)... TX (PRWEB) September 23, 2014 As ... taken before making a purchase. It’s difficult to trust ... it’s easy for them to manipulate their customers into ... this dilemma, but they tend to lack in depth ... Health Reports was founded to fix this issue ...
(Date:9/23/2014)... used to diagnose lung cancer may not be as reliable ... a new analysis says. One noninvasive way of ... as functional imaging. For lung cancer, a specific type of ... authors. Cancerous tumors generally look different on FDG-PET images ... have cancer, according to background information in the study. But, ...
(Date:9/23/2014)... What information do patients need ... Forum (NQF) released a report ( http://bit.ly/1DwekE9 ), ... infographic ( http://bit.ly/1tX3lzA ) resulting from an in-depth ... patients define affordability, and what information and changes ... possible healthcare at the lowest possible cost. ...
(Date:9/23/2014)... TUESDAY, Sept. 23, 2014 (HealthDay News) -- The ... unapproved prescription drugs is growing, so doctors need ... Food and Drug Administration warned Tuesday. In ... so widespread that it has launched a program ... and administrators about proper drug purchasing procedures. The ...
Breaking Medicine News(10 mins):Health News:Academia Sinica, UC Davis sign agreement on exchanges and tech transfer 2Health News:Consumer Health Reports Debuts Revolutionary Review Website 2Health News:Lung Infections May Hamper Ability to Detect Lung Cancer 2Health News:Finding Affordable Care: Asking the Right Question is Key 2
... Alan Mozes HealthDay Reporter , TUESDAY, Dec. 20 ... wriggling) competition in cleaning troublesome wounds: maggots. To the ... suggests that bagging up live, sterile fly larvae in tightly ... be a quick, safe and effective way to clear ...
... Gordon HealthDay Reporter , TUESDAY, Dec. 20 (HealthDay ... a doctor should decide if complications are severe enough to ... (ADA) says. In a new position statement published in ... advises against blanket bans or restrictions. Instead, it recommends that ...
... accounts for the majority of all thyroid malignancies, which primarily ... nodes in the neck in these cancer patients may help ... thyroid cancer metastasizes, lymph nodes in the neck may be ... not be detected by ultrasounds done before surgery to remove ...
... 20 (HealthDay News) -- Increasing concentrations of two ... samples collected in the Great Lakes region between ... The chemicals are used to reduce flammability in ... and polyurethane foams. They are 2-ethylhexyl tetrabromobenzoate [TBB] ...
... 20, 2011Women who are at risk for breast cancer may ... has found. The majority of women with hereditary breast ... or BRCA2 genes, which normally suppress the growth of breast ... at St. Michael,s Hospital, said his research team was surprised ...
... HealthDay Reporter , MONDAY, Dec. 19 (HealthDay News) -- ... likely to develop inflammatory bowel disease such as Crohn,s disease ... according to a new long-term study. Endometriosis ... grows outside of the uterus. Symptoms include abdominal pain, ...
Cached Medicine News:Health News:Maggots Quickly Clean Up Wounds, Study Shows 2Health News:Maggots Quickly Clean Up Wounds, Study Shows 3Health News:Driving Isn't An Issue for Most People With Diabetes 2Health News:Driving Isn't An Issue for Most People With Diabetes 3Health News:Removal of lymph nodes during surgery for thyroid cancer may be beneficial 2Health News:Removal of lymph nodes during surgery for thyroid cancer may be beneficial 3Health News:Buildup of Newer Flame Retardants Concerns Scientists 2Health News:Breast cancer and heart disease may have common roots 2Health News:Endometriosis Tied to Higher Risk of Crohn's, Colitis 2
Femoral selective diagnostic catheter.The material used is polyurethane (DUCOR). All selective shapes have thrulumen design. Guidewire campatibility is 0.038". Packaging 5/Box....
Terumo's Outlook offers superior torque and precision control. It's patient-friendly, high torque design makes it the catheter of choice for demanding angiography....
Femoral selective catheter. Catheter material used is polyurethane (TRICOR). Guidewire campatibility is 0.038". Packaging 5/Box....
Cordis DUCOR Catheters are available in a broad variety of French sizes and configurations. These catheters combine an atraumatic tip with either a braided or non-braided body....
Medicine Products: