Navigation Links
Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer
Date:6/2/2009

ed gastrointestinal and other severe toxicities.

About OPAXIO(TM)

OPAXIO(TM) (paclitaxel poliglumex, CT-2103), which was formerly known as XYOTAX(TM), is an investigational, biologically enhanced, chemotherapeutic that links paclitaxel, the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer, which results in a new chemical entity. When bound to the polymer, the chemotherapy is rendered inactive, potentially sparing normal tissue's exposure to high levels of unbound, active chemotherapy and its associated toxicities. Blood vessels in tumor tissue, unlike blood vessels in normal tissue, are porous to molecules like polyglutamate. Based on preclinical studies, it appears that OPAXIO is preferentially distributed to tumors due to their leaky blood vessels and trapped in the tumor bed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may be influenced by estrogen, which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer compared to standard therapies.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit www.CellTherapeutics.com.

Sign up for email alerts and get RSS feeds at our Web site, http://www.celltherapeutics.com/investors_news.htm

This
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer
2. Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimers Disease
3. Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated
4. Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
5. Ceremeds OSTENE(R) Stops Bone Bleeding Without Added Risk of Surgical Infection, New Study Finds
6. Zetia Does Not Reduce Carotid Plaque Size When Added to Zocor
7. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
8. Muscadine Grape Skin Dietary Supplement Protects against Cancer Therapy Radiation Side Effects
9. Winning the War on Cancer: The Critical Role of Radiation Oncology
10. Breast MRI Scan Could Determine Need for Radiation Therapy
11. High Intensity Focused Ultrasound for Locally Recurrent Prostate Cancer Following External Beam Radiation Therapy Investigated in Phase III Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... research firm Kalorama information says that 2014 will be ... medical device industry.  The firm thinks the $360 billion-dollar ... growth this year, which led firms to look to ... entrance by acquisition into new competitive zones.  The company ... Global Market for Medical Devices, 5 th Edition ...
(Date:11/21/2014)... 21. November 2014 Michael DeMarco ... Morgen des 14. Februar 2014 zugetragen hat. Seine Tochter ... vergessen. Video - http://youtu.be/5cVoMCe0uiE ... war, mein morgendliches Training zu machen", erzählt Michael ... der Zeit begeisterte Anhänger der CrossFit-Trainingsmethode. Ich war ...
(Date:11/21/2014)... 2014  Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ... underwritten public offering of $50,000,000 of shares of its ... The offering will consist of 49,751,244 shares of common ... share.  Lexicon has also granted the underwriters a 30-day ... common stock.  All of the shares in the offering ...
Breaking Medicine Technology:Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 3Lexicon Announces Pricing Of Common Stock Offering 2Lexicon Announces Pricing Of Common Stock Offering 3
... ROCKVILLE, Md. , Feb. 8 Novavax, Inc. (Nasdaq: ... that began in May of 2009 among healthy adults 18 to ... (VLP) vaccine. The vaccine matched the influenza strains recommended for the ... /10/2007, and B/ Florida /04/2006 strains. The study enrolled 241 subjects, ...
... , NEW YORK , Feb. 8 ... leader in online medical equipment auctions, is reporting strong  and ... used medical equipment  across all categories including hospitals. In a ... of its auctions increase in three leaps with from 8,000 ...
Cached Medicine Technology:NOVAVAX Reports Additional Positive Data from Its Trivalent Seasonal Influenza (VLP) Vaccine Clinical Study in Healthy Adults 2NOVAVAX Reports Additional Positive Data from Its Trivalent Seasonal Influenza (VLP) Vaccine Clinical Study in Healthy Adults 3NOVAVAX Reports Additional Positive Data from Its Trivalent Seasonal Influenza (VLP) Vaccine Clinical Study in Healthy Adults 4DOTmed Reports Explosive Growth in Online Medical Equipment Auctions 2DOTmed Reports Explosive Growth in Online Medical Equipment Auctions 3
(Date:11/23/2014)... BambooFlooringChina.com , the world’s leader in bamboo ... bamboo flooring collection. Now, the business is announcing big ... the promotion is valid until Dec. 20, 2014. , The ... and dust-free surface, which makes it very easy to maintain. ... company wants to make its website the best shopping platform ...
(Date:11/22/2014)... November 23, 2014 Every year AlignLife ... communities. AlignLife experience rapid growth in the Greenville, SC ... unique opportunity. AlignLife of Simpsonville will be ... for their first annual Toy Drive. These six offices ... would support with this year's toy drive. With so ...
(Date:11/22/2014)... Cancer researchers in New York and ... communication tunnels and the growth and spread of mesothelioma. ... on the Surviving Mesothelioma website. , Doctors at ... Minnesota have just released their study on tunneling nanotubes ... cells. They found that mesothelioma cells contain ...
(Date:11/22/2014)... 23, 2014 Recently, UWDress.com, a successful wedding ... wedding guest attire in order to prepare for the ... up to 70% off. , UWDress.com is a reliable ... very beautiful, especially the new items -- formal wedding guest ... the current market, including superstar and princess. As one of ...
(Date:11/22/2014)... Recently, Locks-Magnetic.com , one of the successful ... mag locks for glass doors online. In addition, the ... fresh products. Customers can get more information on its ... in excellent performance. Customers who want to buy this ... possible. They also can enjoy the one-stop shopping ...
Breaking Medicine News(10 mins):Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Greenville Area AlignLife Offices Join Together for a Local Toy Drive 2Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2Health News:Discounted Mag Locks for Glass Doors Revealed by Locks-Magnetic.com 2
... Elementary,school students will eat more whole grains ... school lunches, a new University of,Minnesota study shows., ... part of a healthy diet,but children and pre-teens ... the university,s department of food science and nutrition,monitored ...
... National Adoption Day is November,15 as part ... civic and,faith-based groups, corporations, educators and others generate ... can be ordered at, http://www.davethomasfoundationforadoption.org ., It ... care,adoption awareness, including A Child is Waiting: A ...
... Patients whose nose has been destroyed by a tumor or ... ranges among the most challenging tasks in plastic surgery. Helmut ... reconstruction surgery in the current issue of Deutsches rzteblatt ... The authors present the case of a woman who had ...
... biblical times, leprosy, also known as Hansen,s disease, continues ... 150 cases are diagnosed each year with 3,000 people ... James Krahenbuhl, Ph.D., director of the Health Resources Service ... LA. "We believe there are more cases of leprosy ...
... offers more opportunities for frequent pharmacy customers to save ... ... 7 In the face of challenging,economic times, JEWEL-OSCO PHARMACY(TM) is ... prescription medications,properly and take preventative measures, such as flu immunizations, to,maintain ...
... 7 /Xinhua-PRNewswire-FirstCall/ -- China,Pharma Holdings, Inc. ("China Pharma") ... generic and branded speciality,pharmaceutical products in China, today ... 2008., Financial Highlights -- 3Q08 ... -- $35.6 Million Revenue for nine months ended ...
Cached Medicine News:Health News:Dave Thomas Foundation for Adoption Offers Free Foster Care Adoption Awareness Toolkits 2Health News:Forgotten, but not gone: Leprosy still present in the US 2Health News:JEWEL-OSCO(R) Extends Prescription Plus Rewards Program 2Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 2Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 3Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 4Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 5Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 6Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 7Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 8Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 9Health News:China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates 10
... Fast and easy voice access to ... Telesensorys SoundAdvice is easy and intuitive, enabling ... touching your keyboard. With the VoiceBox Voice ... computer about hundreds of subjects and topics ...
... and painless method of stimulating the peripheral ... two magnetic stimulation devices, the MES-10 and ... The Hight Speed MES-10 magnetic stimulator ... 25 Hz at full power. Several ...
... lightest, most advanced defibrillator monitor ever made, with ... pounds (5kg). Half the weight and a third ... the M Series has everything you need for ... pacing, ECG with advanced monitoring, built-in AC or ...
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
Medicine Products: