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Packaging therapeutic RNAs for targeted treatment of breast cancer
Date:4/18/2012

only in their intended targets, the breast cancer cells.

"PLK1 is a ubiquitously expressed gene," Lieberman noted, "but because we targeted siRNA delivery only to HER2-expressing tumor cells, we could silence it with great specificity and no toxicity to other tissues."

Using the antibody-protamine delivery platform, the team could even deliver cocktails of siRNAs silencing different genes—AKT and CCND1, in addition to PLK1—for a synergistic effect against the mice's tumors.

Lieberman sees great promise for this technique for a broad range of cancers and other disease. "The platform could be used to target siRNAs therapeutically to any cell for which we have a cell surface marker to target. We have also used it to target lymphocytes, suggesting it could be useful against lymphomas and leukemias and as a way of countering organ rejection."

This study was supported by the U.S. Department of Defense Breast Cancer Research Program, the National Basic Research Program of China and the Guangdong Natural Science Foundation.

Boston Children's Hospital is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including nine members of the National Academy of Sciences, 11 members of the Institute of Medicine and nine members of the Howard Hughes Medical Institute comprise Boston Children's research community. Founded as a 20-bed hospital for children, Boston Children's Hospital today is a 395 bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Boston Children's is also the primary pediatric teaching affiliate of Harvard Medical School. For more information about research and clinical innovation at Children's, visit:

SOURCE Boston Children's Hospital
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