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Pacira Pharmaceuticals Highlights Additional Safety Data on EXPAREL™ for Postsurgical Pain Relief at 2011 American Academy of Orthopaedic Surgeons Annual Meeting
Date:2/15/2011

SAN DIEGO, and PARSIPPANY, N.J., Feb. 15, 2011 /PRNewswire/ -- Pacira Pharmaceuticals, Inc., (Nasdaq: PCRX), an emerging specialty pharmaceutical company, today announced that additional safety data are being highlighted from its Phase 3 trial of EXPAREL™ (bupivacaine extended-release liposome injection) in bunionectomy. The data showed comparable safety in wound healing and significantly improved efficacy in pain reduction compared to placebo. These results are being highlighted in a poster presentation at the 2011 American Academy of Orthopaedic Surgeons Annual Meeting in San Diego, Calif.

"Data show that EXPAREL did not alter wound healing and no patients experienced malunion or non-union, both of which are critical factors considered when used to determine the appropriate postsurgical analgesic therapy," said Eugene R. Viscusi, M.D., Director, Acute Pain Management, Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia. "These data, coupled with efficacy data, demonstrate that a single administration of EXPAREL enabled more patients to be pain-free for up to 48 hours post surgery, and significantly delayed usage of, or decreased the need for opioid rescue medication. These overall findings support that EXPAREL may be a useful addition to postsurgical analgesic."

The multicenter, parallel-group, randomized, double-blind study of 193 patients evaluated the efficacy and safety of the intraoperative administration of EXPAREL compared with placebo in bunionectomy patients. The company reported preliminary efficacy data in October 2009, and presented updated efficacy data during the Orthopaedic Research Society meeting (January 2011). These study results include:

  • Statistically significantly more patients treated with EXPAREL were pain-free at 2, 4, 8 and 48 hours compared to placebo (p<0.05) and statistically
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  • SOURCE Pacira Pharmaceuticals, Inc.
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