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Pacira Pharmaceuticals, Inc. Announces New Data Demonstrating Longer Time to First Opioid Use and Reduction in Opioid-Related Adverse Events With EXPAREL™ Compared to Bupivacaine HCl
Date:10/19/2011

tes of administration (wound infiltration, subcutaneous, epidural or nerve block) were studied.

The key findings include:

  • EXPAREL exhibited an initial peak in plasma concentration 0.25-2 hours after administration (likely due to the small amount of extraliposomal bupivacaine present in EXPAREL) followed by a second peak at 12-24 hours (due to the slow and prolonged release of bupivacaine from the DepoFoam). Bupivacaine HCl exhibited a single peak in plasma concentration at 0.25-2 hours followed by a rapid decline toward zero.
  • Even at doses up to 600 mg, the maximal plasma concentration of EXPAREL was 935 ng/mL, which is 2- to 4-fold below the minimal toxicity threshold for bupivacaine HCl (central nervous system effects are usually first seen at bupivacaine levels of  >2000 ng/mL; cardiac system effects are usually first seen at levels of >4000 ng/mL).
  • Consistent plasma curves were observed for all doses of EXPAREL, suggesting that dosing can safely be adapted to meet the specific needs of each surgical model.

"These data show that EXPAREL delivers bupivacaine over three days with the well-established DepoFoam carrier matrix, providing postsurgical pain relief while extending the traditional duration of action from seven hours to up to 72 hours," said Dr. Hu. "This bimodal release may be beneficial in the multimodal treatment of postsurgical pain."

"The body of clinical evidence that supports the utility of EXPAREL as a postsurgical pain management therapy continues to grow and we believe these data presented at ACCP further support its potential clinical and health economic utility," said Dave Stack, president and chief executive officer of Pacira Pharmaceuticals, Inc. "Based upon the positive feedback we have received from a variety of clinical key opinion leaders and hospital organizations, we believe that EXPAREL may become a valuable therapeut
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SOURCE Pacira Pharmaceuticals, Inc.
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