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Pacira Pharmaceuticals, Inc. Announces New Data Demonstrating Longer Time to First Opioid Use and Reduction in Opioid-Related Adverse Events With EXPAREL™ Compared to Bupivacaine HCl
Date:10/19/2011

fic results include:

  • A median TTFO that was 3.5 times longer for patients receiving EXPAREL compared to patients receiving bupivacaine HCl (9.9 hours vs 2.7 hours, respectively).
  • A 50% reduction in the total amount of morphine-equivalent opioids consumed for patients receiving EXPAREL compared to patients receiving bupivacaine HCl (7.9 mg vs 15.8 mg, respectively).
  • A 46% reduction in the mean number of ORAEs for patients receiving EXPAREL compared to patients receiving bupivacaine HCl (0.25 vs 0.46, respectively).
  • Less pain over 72 hours was demonstrated for patients receiving EXPAREL compared to patients receiving bupivacaine HCl, as evidenced by an area under the curve analysis, a measure of pain over time (AUC0-72 315 vs 427, respectively).

"Postsurgical patients often require opioids, which along with pain relief, cause a plethora of costly and sometimes life-threatening side effects," said Dasta. "In this pooled analysis, patients receiving EXPAREL had less opioid consumption and fewer ORAEs over 72 hours. In my experience, patients who have no or few ORAEs are more likely to benefit from an improved recovery experience. Pharmacists should be particularly interested in this unique approach to postsurgical analgesia as it has not only clinical, but potentially economic implications."

Additionally, Deedee Hu, PharmD, clinical specialist in the Department of Critical Care and Cardiology at Memorial Hermann Memorial City Medical Center in Houston, Texas, also presented new data during a poster presentation at ACCP today demonstrating that EXPAREL exhibits pharmacokinetic properties consistent with bimodal and sustained-release formulations. These data were collected from a total of 446 individuals receiving 75 mg to 750 mg of EXPAREL or bupivacaine HCl across 11 studies. Various surgical models (hemorrhoidectomy, herniorrhaphy, bunionectomy or total knee arthroplasty) and rou
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SOURCE Pacira Pharmaceuticals, Inc.
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