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Pacira Pharmaceuticals, Inc. Announces New Data Demonstrating Longer Time to First Opioid Use and Reduction in Opioid-Related Adverse Events With EXPAREL™ Compared to Bupivacaine HCl
Date:10/19/2011

PARSIPPANY, N.J., Oct. 19, 2011 /PRNewswire/ -- Pacira Pharmaceuticals, Inc. (Nasdaq: PCRX) today announced new data demonstrating a reduction in opioid burdens with EXPAREL™ (bupivacaine liposome extended-release injectable suspension) at doses up to and including 300 mg compared to bupivacaine HCl in a multimodal setting at the 2011 Annual Meeting of the American College of Clinical Pharmacy (ACCP) in Pittsburgh. These data are the result of a pooled analysis of five trials conducted for postsurgical pain management.

Currently under review with the U.S. Food and Drug Administration, EXPAREL is an innovative long-acting bupivacaine that has been evaluated in multiple Phase 2 and Phase 3 clinical studies to assess prolonged postsurgical analgesia for up to 72 hours with a single-dose local administration at the surgical site. The drug combines bupivacaine with DepoFoam®, a proven product delivery technology that encapsulates medications and delivers them over a desired time period.

Joseph F. Dasta, M.Sc., FCCM, FCCP, adjunct professor at the University of Texas, College of Pharmacy, presented the data, which evaluated the use of EXPAREL at doses up to and including 300 mg compared to bupivacaine HCl at doses up to and including 150 mg administered via wound infiltration across three surgical models including hemorrhoidectomy, total knee arthroplasty and herniorrhaphy. Data pooled from these five active-control, double-blind, randomized, multicenter, parallel-group trials of more than 700 patients demonstrated that across all surgical models, EXPAREL resulted in longer time to first opioid use (TTFO), a reduced overall consumption of opioids, fewer opioid-related adverse events (ORAEs) and better pain control compared to bupivacaine HCl. Each finding was statistically significant (P<0.0001).

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SOURCE Pacira Pharmaceuticals, Inc.
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