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Pacira Pharmaceuticals, Inc. Announces EXPAREL™ Data Presentations
Date:5/5/2011

PARSIPPANY, N.J., May 5, 2011 /PRNewswire/ -- Pacira Pharmaceuticals, Inc. (Nasdaq: PCRX), an emerging specialty pharmaceutical company, today announced that clinical and preclinical data highlighting the safety and efficacy of EXPAREL™ will be presented at two medical meetings.

New Phase 3 data on the use of EXPAREL in the treatment of postsurgical pain after augmentation mammoplasty will be presented by Sergio Bergese, M.D., associate professor of anesthesiology and neurological surgery, The Ohio State University, at the Society for Ambulatory Anesthesia (SAMBA) 26th Annual Meeting in San Antonio on Saturday, May 7, 2011. Dr. Bergese's presentation, titled "EXPAREL™ (Bupivacaine Extended-Release Liposome Injection), An Investigational Analgesic, Provides Postsurgical Pain Relief and Decreased Opioid Use as Demonstrated by Integrated Analysis" evaluated the extent and duration of the analgesic effect of EXPAREL in patients undergoing augmentation mammoplasty, the most commonly performed plastic surgery procedure in the United States.

Key findings from this study include:

  • A total of 136 patients were treated at 11 clinical sites in the U.S.
  • When the pain score and the opioid usage were combined using the integrated rank analysis of Silverman, statistical significance was achieved at multiple time points (p<0.05)
  • The mean total amount of opioid rescue used (morphine equivalents) was lower with EXPAREL at all time points through 96 hours
    • The difference between groups was statistically significant for the time intervals of 0–24 hours and 0–48 hours
  • The overall incidence of treatment-emergent adverse events was approximately 73% in both treatment groups
  • There were no serious adverse events, deaths or withdrawals from
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SOURCE Pacira Pharmaceuticals, Inc.
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